CA 074 TFA
CA 074 TFA structure
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Common Name | CA 074 TFA | ||
|---|---|---|---|---|
| CAS Number | 134448-10-5 | Molecular Weight | 383.43900 | |
| Density | 1.267g/cm3 | Boiling Point | 728.9ºC at 760mmHg | |
| Molecular Formula | C18H29N3O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 394.7ºC | |
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Human cystatin C: a new biomarker of idiopathic pulmonary fibrosis?
Proteomics. Clin. Appl. 8(5-6) , 447-53, (2014) Human idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disorder with a poor prognosis. The identification of a new and specific biomarker in bronchoalveolar lavage fluids (BALFs) may assist in the diagnosis of the disease.Characterizatio... |
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Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.
PLoS ONE 6(11) , e27197, (2011) Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughput screening campaigns and require further analysis to dist... |
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Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex.
Biochim. Biophys. Acta 1597(2) , 244-51, (2002) In order to elucidate the substrate specificity of the Sn subsites (n=1-3) of cathepsin B, its crystal structure inhibited by E64c [(+)-(2S,3S)-3-(1-[N-(3-methylbutyl)amino]-leucylcarbonyl)oxirane-2-carboxylic acid] was analyzed by the X-ray diffraction metho... |
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Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition.
Acta Neuropathol. 104(3) , 267-72, (2002) Previously, we reported "calpain-induced leakage of lysosomal enzyme cathepsin" as a mechanism of ischemic neuronal death specific for primates. Cathepsin inhibitors such as CA-074 and E-64c were demonstrated to significantly inhibit hippocampal neuronal deat... |
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Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.
PLoS ONE 6 , e20617, (2011) Mitochondria are indispensable in the life and death of many types of eukaryotic cells. In pancreatic beta cells, mitochondria play an essential role in the secretion of insulin, a hormone that regulates blood glucose levels. Unregulated blood glucose is a ha... |
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Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice.
HBPD INT 12(1) , 80-6, (2013) Increasing evidence suggests that the inactivation of cathepsin B attenuates hepatocyte apoptosis and liver damage. This study aimed to investigate the protective effects of a cathepsin B inhibitor (CA-074me) on lipopolysaccharide (LPS)/D-galactosamine (D-Gal... |
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The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.
Proc. Natl. Acad. Sci. U. S. A. 102(30) , 10493-8, (2005) The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papai... |
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Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Eukaryotic Cell 2(6) , 1234-45, (2003) The process of excystment of Sterkiella histriomuscorum (Ciliophora, Oxytrichidae) leads in a few hours, through a massive influx of water and the resorption of the cyst wall, from an undifferentiated resting cyst to a highly differentiated and dividing veget... |
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Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.
Biochem. J. 381(Pt 2) , 511-7, (2004) The crystal structure of the inhibitor NS-134 in complex with bovine cathepsin B reveals that functional groups attached to both sides of the epoxysuccinyl reactive group bind to the part of active-site cleft as predicted. The -Leu-Pro-OH side binds to the pr... |
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Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells.
Anal. Biochem. 353(1) , 57-62, (2006) We established a novel protocol for lithium dodecyl sulfate (LDS) gelatin zymography, which operates under reducing conditions and at a slightly acidic pH value (6.5). This zymographic assay is based on polyacrylamide gel electrophoresis and facilitates the e... |