7-(4-Methoxybenzylamino)-4-nitrobenzoxadiazole
7-(4-Methoxybenzylamino)-4-nitrobenzoxadiazole structure
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Common Name | 7-(4-Methoxybenzylamino)-4-nitrobenzoxadiazole | ||
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| CAS Number | 33984-50-8 | Molecular Weight | 300.26900 | |
| Density | 1.438 g/cm3 | Boiling Point | 500.8ºC at 760 mmHg | |
| Molecular Formula | C14H12N4O4 | Melting Point | 178-182ºC | |
| MSDS | Chinese USA | Flash Point | 256.7ºC | |
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Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.
Clin. Epigenetics. 7 , 52, (2015) Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilised cancer cell lines or clinical samples, where it... |
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Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.
J. Physiol. 593 , 2427-46, (2015) Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a gated pathway for chloride movement, causes the common life-shortening genetic disease cystic fibrosis (CF). Towards the development of a sheep model of CF, we have investigated ... |
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Nutritional evaluation of Australian microalgae as potential human health supplements.
PLoS ONE 10(2) , e0118985, (2015) This study investigated the biochemical suitability of Australian native microalgal species Scenedesmus sp., Nannochloropsis sp., Dunaliella sp., and a chlorophytic polyculture as nutritional supplements for human health. The four microalgal cultures were har... |
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Electrochemical detection of anti-tau antibodies binding to tau protein and inhibition of GSK-3β-catalyzed phosphorylation.
Anal. Biochem. 496 , 55-62, (2016) Tau protein hyperphosphorylation triggers tau aggregation and its toxicity, leading to neuronal death and cell-to-cell toxicity. Hence, inhibition of protein kinases is a viable tool toward reduction of tau toxicity. By targeting various epitopes of Tau441 pr... |
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Targeting of P-Element Reporters to Heterochromatic Domains by Transposable Element 1360 in Drosophila melanogaster.
Genetics 202 , 565-82, (2016) Heterochromatin is a common DNA packaging form employed by eukaryotes to constitutively silence transposable elements. Determining which sequences to package as heterochromatin is vital for an organism. Here, we use Drosophila melanogaster to study heterochro... |
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Limitation of the activated partial thromboplastin time as a monitoring method of the direct thrombin inhibitor argatroban.
Int. J. Lab. Hematol. 37 , 834-43, (2016) Argatroban is licensed for patients with heparin-induced thrombocytopenia and monitoring is conventionally by activated partial thromboplastin time (APTT) ratio with a target of 1.5-3.0 and not exceeding 100 s. The APTT may be influenced by coagulopathies, lu... |
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Non-referenced genome assembly from epigenomic short-read data.
Epigenetics 9(10) , 1329-38, (2014) Current computational methods used to analyze changes in DNA methylation and chromatin modification rely on sequenced genomes. Here we describe a pipeline for the detection of these changes from short-read sequence data that does not require a reference genom... |
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Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture.
Surg. Endosc. 29 , 1862-70, (2015) Single preoperative biliary drainage for malignant perihilar biliary stricture occasionally fails to control jaundice and cholangitis. Multiple biliary drainage is required in such cases, but their clinical background is unclear. We determined the clinical ch... |
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Pros and cons of methylation-based enrichment methods for ancient DNA.
Sci. Rep. 5 , 11826, (2015) The recent discovery that DNA methylation survives in fossil material provides an opportunity for novel molecular approaches in palaeogenomics. Here, we apply to ancient DNA extracts the probe-independent Methylated Binding Domains (MBD)-based enrichment meth... |
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Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma.
Oncotarget 7 , 1960-72, (2016) Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled... |