B-HT 920
B-HT 920 structure
|
Common Name | B-HT 920 | ||
|---|---|---|---|---|
| CAS Number | 36085-73-1 | Molecular Weight | 282.233 | |
| Density | N/A | Boiling Point | 364.6ºC at 760mmHg | |
| Molecular Formula | C10H17Cl2N3S | Melting Point | 245ºC dec. | |
| MSDS | Chinese USA | Flash Point | 174.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions.
Neuroreport 26 , 1126-32, (2015) Although 6-hydroxydopamine-induced (6-OHDA-induced) rats are a well-known Parkinson's disease model, the effects of dopamine D2 agonists in mice with 6-OHDA-induced lesions are not completely understood. We produced mice with 6-OHDA-induced lesions and measur... |
|
|
Mechanism of decongestant activity of alpha 2-adrenoceptor agonists.
Pulm. Pharmacol. Ther. 21(3) , 449-54, (2008) The vascular bed in nasal mucosa of different species, including human, is highly vascularized and an extensive sinusoidal network of large capacitance vessels is present deep within the submucosa. When this network of venous sinusoids is engorged with blood,... |
|
|
Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture.
Neurosci. Res. 46(4) , 523-32, (2003) Paraquat (1,1'-dimethyl-4,4'-bipyridinium, PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between the incidence of the disease and the amount of PQ used. In this study, we examined PQ toxicity in rat ... |
|
|
Impaired endothelial alpha-2 adrenergic receptor-mediated vascular relaxation in the fructose-fed rat.
Hypertens. Res. 25(2) , 197-202, (2002) To investigate the vascular endothelial dysfunction in the insulin resistance syndrome, muscarinic and alpha2-adrenergic mediated relaxations were studied in the fructose-fed rat. Male Sprague-Dawley rats were fed either fructose-rich chow (FFR, n=14) or norm... |
|
|
Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca.
Eur. J. Pharmacol. 489(1-2) , 101-10, (2004) It has been suggested that the combination of dietary Ca and Ca2+ channel antagonists could have a synergic antihypertensive effect. In this study, 3-week-old male spontaneously hypertensive rats (SHR) were randomized into four groups of animals. Two of these... |
|
|
alpha2-adrenoceptor agonists as nasal decongestants.
Pulm. Pharmacol. Ther. 20(2) , 149-56, (2007) Nasal congestion, one of the major disease features of rhinitis, is induced by the filling of venous sinusoids causing mucosal engorgement with resultant obstruction of nasal airflow. The only available drugs that directly target the underlying vascular featu... |
|
|
Antagonistic activity of ascorbic acid (vitamin C) on dopaminergic modulation: apomorphine-induced stereotypic behavior in mice.
Pharmacology 77(1) , 38-45, (2006) Among the various neurotransmitter systems implicated in the mechanism of action of ascorbic acid (vitamin C), the relationship between the dopaminergic system and ascorbic acid is not particularly clear. Ascorbic acid is speculated to have an antagonistic ef... |
|
|
The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells.
Neurotoxicology 31(6) , 701-8, (2010) Talipexole is a non-ergot dopamine (DA) agonist that has been used in the treatment of Parkinson's disease. In the present study, we examined the effect of talipexole on paraquat (PQ)-induced N27 cell death and the intracellular pathways involved in this effe... |
|
|
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Fundam. Clin. Pharmacol. 16(4) , 281-7, (2002) The experiments in this study were designed to investigate the potential relaxing effects of different compounds known as alpha2-imidazoline ligands (either agonists or antagonists) in isolated rat arteries, and to test the role of nitric oxide (NO) and prost... |
|
|
Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells.
J. Pharmacol. Toxicol. Methods 45(1) , 17-37, (2001) Most drugs have some efficacy so that improved methods to determine the relative intrinsic efficacy of partial agonists should be of benefit to preclinical and clinical investigators. We examined the effects of partial D(1) or partial D(2) dopamine agonists u... |