Diethyl fumarate
Diethyl fumarate structure
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Common Name | Diethyl fumarate | ||
|---|---|---|---|---|
| CAS Number | 623-91-6 | Molecular Weight | 172.178 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 214.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H12O4 | Melting Point | 41641ºC | |
| MSDS | Chinese USA | Flash Point | 93.3±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.
PLoS ONE 9(6) , e98385, (2014) Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon doub... |
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Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst.
J. Biomater. Sci. Polym. Ed. 13(1) , 95-108, (2002) Diethyl fumarate and propylene glycol were reacted in the presence of a zinc chloride catalyst to synthesize poly(propylene fumarate) (PPF) over a period of 12 hours. The kinetics of the transesterification polymerization at 130 degrees C, 150 degrees C, and ... |
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Facile preparation of the tosylhydrazone derivatives of a series of racemic trans-3,4-substituted cyclopentanones.
Molecules 17(1) , 1-14, (2011) We report the synthesis and characterization of a variety of trans-3,4-substituted cyclopentanones and the corresponding tosylhydrazone derivatives starting with diethyl fumarate. Protection of the keto group followed by selective monohydrolysis of esters was... |
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Investigations of glutathione conjugation in vitro by 1H NMR spectroscopy. Uncatalyzed and glutathione transferase-catalyzed reactions.
Chem. Res. Toxicol. 8(5) , 780-91, (1995) Conjugation reactions of glutathione (GSH) and related thiols with diethyl maleate (DEM) and other alpha, beta-unsaturated carbonyl compounds have been investigated by 1H NMR spectroscopy. The products from the reaction with DEM and diethyl fumarate (DEF) are... |
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Contact urticaria from diethyl fumarate.
Contact Dermatitis 12(3) , 139-40, (1985) The contact urticariagenic properties of diethyl fumarate were studied using the guinea pig ear swelling assay and by open application on the human upper back skin. Diethyl fumarate caused non-immunologic contact urticaria in both human and guinea pig skin, a... |
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Development of 3D PPF/DEF scaffolds using micro-stereolithography and surface modification.
J. Mater. Sci. Mater. Med. 20(1) , 271-9, (2009) Poly(propylene fumarate) (PPF) is an ultraviolet-curable and biodegradable polymer with potential applications for bone regeneration. In this study, we designed and fabricated three-dimensional (3D) porous scaffolds based on a PPF polymer network using micro-... |
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Effect of fumaric acid, its dimethylester, and topical antipsoriatic drugs on epidermal differentiation in the mouse tail model.
Skin Pharmacol. 9(2) , 99-103, (1996) Fumaric acid, fumaric acid dimethylester, and the dithranol derivative C4-lactone were studied in the mouse tail test to evaluate their effects on epidermal cell differentiation compared with other topical antipsoriatic drugs, such as betamethasone, calcipotr... |
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Towards excimer-laser-based stereolithography: a rapid process to fabricate rigid biodegradable photopolymer scaffolds.
J. R. Soc. Interface 9(76) , 3017-26, (2012) We demonstrate high-resolution photocross-linking of biodegradable poly(propylene fumarate) (PPF) and diethyl fumarate (DEF) using UV excimer laser photocuring at 308 nm. The curing depth can be tuned in a micrometre range by adjusting the total energy dose (... |
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Reactivity of vinyl ethers and vinyl ribosides in UV-initiated free radical copolymerization with acceptor monomers.
Biomacromolecules 11(9) , 2415-21, (2010) The reactivity of various vinyl ethers and vinyloxy derivatives of ribose in the presence of diethyl fumarate or diethyl maleate was investigated for evaluating the potential of donor-acceptor-type copolymerization applied to unsaturated monomers derived from... |
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Application of multivariate curve resolution methods to on-flow LC-NMR.
J. Chromatogr. A. 1096(1-2) , 2-15, (2005) The application of evolving window factor analysis (EFA), subwindow factor analysis (SFA), iterative target transformation factor analysis (ITTFA), alternating least squares (ALS), Gentle, automatic window factor analysis (AUTOWFA) and constrained key variabl... |