Hygromycin B
Hygromycin B structure
|
Common Name | Hygromycin B | ||
|---|---|---|---|---|
| CAS Number | 31282-04-9 | Molecular Weight | 527.520 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 897.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H37N3O13 | Melting Point | 160-180ºC | |
| MSDS | Chinese USA | Flash Point | 496.7±34.3 °C | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
|
P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
Mol. Cancer 13 , 259, (2014) Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PIK3CA, BRAF, and others that drive tumor growth. Some patien... |
|
|
Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival.
Stem Cell Res. 12(2) , 584-98, (2014) The hTERT-immortalization of human bone marrow-derived Mesenchymal Stromal Cells (hMSCs) was proposed to address availability/standardization issues for experimental or clinical studies, but raised concerns due to possible uncontrolled growth or malignant cel... |
|
|
Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells.
EMBO J. 31(18) , 3678-90, (2012) The eukaryotic genome is replicated according to a specific spatio-temporal programme. However, little is known about both its molecular control and biological significance. Here, we identify mouse Rif1 as a key player in the regulation of DNA replication tim... |
|
|
Extension of yeast chronological lifespan by methylamine.
PLoS ONE 7(11) , e48982, (2012) Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research. We have analyzed chronologic... |
|
|
Expression of wheat Na(+)/H(+) antiporter TNHXS1 and H(+)- pyrophosphatase TVP1 genes in tobacco from a bicistronic transcriptional unit improves salt tolerance.
Plant Mol. Biol. 79(1-2) , 137-55, (2012) Abiotic stress tolerance of plants is a very complex trait and involves multiple physiological and biochemical processes. Thus, the improvement of plant stress tolerance should involve pyramiding of multiple genes. In the present study, we report the construc... |
|
|
[Establishment of in vitro culture, plant regeneration and genetic transformation of Camelina sativa].
Tsitol. Genet. 47(3) , 14-20, (2013) The results on in vitro culture establishment, plantlet regeneration and rooting of Camelina sativa cultivar sample Peremozhets and cultivar Mirazh are presented. Effective concentrations of sterilizing agents and duration of plant material treatment were est... |
|
|
Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols.
Plant Cell Rep. 29 , 1203-1213, (2010) Plant transformation protocols generally involve the use of selectable marker genes for the screening of transgenic material. The bacterial gene nptII, coding for a neomycin phosphotransferase, and the hpt gene, coding for a hygromycin phosphotransferase, are... |
|
|
In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.
Br. J. Cancer 108(3) , 570-8, (2013) As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some approved pharmaceuticals exhibit activities against diseases they have n... |
|
|
CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei.
Mol. Biochem. Parasitol. 157(1) , 73-82, (2008) The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive selection for genome integration followed by CRE recombinase-me... |
|
|
Analysis of T-DNA integration and generative segregation in transgenic winter triticale (x Triticosecale Wittmack).
BMC Plant Biol. 12 , 171, (2012) While the genetic transformation of the major cereal crops has become relatively routine, to date only a few reports were published on transgenic triticale, and robust data on T-DNA integration and segregation have not been available in this species.Here, we ... |