Hygromycin B

Modify Date: 2024-01-02 15:51:45

Hygromycin B Structure
Hygromycin B structure
 Common Name Hygromycin B
CAS Number 31282-04-9 Molecular Weight 527.520
Density 1.7±0.1 g/cm3 Boiling Point 897.6±65.0 °C at 760 mmHg
Molecular Formula C20H37N3O13 Melting Point 160-180ºC
MSDS Chinese USA Flash Point 496.7±34.3 °C
Symbol GHS05 GHS06 GHS08
GHS05, GHS06, GHS08		 Signal Word Danger

 Use of Hygromycin B


Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

 Names

Name Hygromycin B
Synonym More Synonyms

 Hygromycin B Biological Activity

Description Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
Related Catalog
Target

Target：Antibacterial; Antifungal[1]
In Vitro Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus[1]. Hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes. Polypeptide synthesis in cell-free extracts from rabbit reticulocytes, wheat germ and yeast is strongly blocked by low concentrations ofhygromycin B. The antibiotic inhibits peptide chain elongation by yeast polysomes by preventing elongation factor EF-2-dependent translocation. The inhibition of translocation by hygromycin B might result from the stabilization of peptidyl-tRNA bound to the ribosomal acceptor site[2].
In Vivo Hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading in vivo[3]. Constitutive expression of the bacterial hygR gene in transgenic mice in vivo confers resistance to hygromycin B[4].
Animal Admin Hygromycin B is dissolved in sterile water. The mice C57BL/6J-TgN(pPWL512hyg)1Ems carrying hygR are treated with a single dose of hygromycin B i.p. at doses that starts at 2.7 mg/kg and increases by 50% for each consecutive dose. Control wild-type C57BL/6J mice are treated with the same volume of sterile saline. Total volume injected is 0.5 mL. The health status and body weights of animals are monitored daily for 10 consecutive days[4].

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 897.6±65.0 °C at 760 mmHg
Melting Point 160-180ºC
Molecular Formula C20H37N3O13
Molecular Weight 527.520
Flash Point 496.7±34.3 °C
Exact Mass 527.232666
PSA 272.06000
LogP 0.64
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.672

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WK2130000
CHEMICAL NAME :
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosyli dene-(1-2-3)-O-beta-D- talopyranosyl-(1-5)-2-deoxy-N-(sup 3)-methyl-
CAS REGISTRY NUMBER :
31282-04-9
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C20-H37-N3-O13
MOLECULAR WEIGHT :
527.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2220 ug/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - aggression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46000 units/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
378 mg/kg/17W-I
TOXIC EFFECTS :
Blood - changes in spleen

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
3 gm/L
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 25,822,1980 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.001 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2770 No. of Facilities: 71 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 357 (estimated)

 Safety Information

Symbol GHS05 GHS06 GHS08
GHS05, GHS06, GHS08
Signal Word Danger
Hazard Statements H301 + H311-H318-H330-H334
Precautionary Statements P260-P280-P284-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T+:Verytoxic;
Risk Phrases R26/27/28;R41;R42/43
Safety Phrases S22-S26-S28-S36/37/39-S45
RIDADR UN 3462
WGK Germany 3
RTECS WK2130000
Packaging Group I
Hazard Class 6.1

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 Synonyms

Destomycin A
O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2- 3)-O-α-D-talopyranosyl-(1->5)-2-deoxy-N3-
EINECS 250-545-5
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-
(3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)octahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetrol (non-preferred name)
HYGROGOLD(TM)
hygrovetine
Hygromix
Hygromix-8
antihelmycin
hygromix2.4
Hygrovetin
MFCD00036846
Hygromix 2.4
Hygrovectine
Hyaromycin B
Hygromycin B
(3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)octahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetrol
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene(1-2-3)-O-β-D-talopyranosyl-(1->)-2-deoxy-N3-methyl-
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl-(1-5)-2-deoxy-N-(sup 3)-methyl-
hydromycinb
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