Imipenem
Imipenem structure
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Common Name | Imipenem | ||
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| CAS Number | 74431-23-5 | Molecular Weight | 317.36 | |
| Density | 1.02 g/mL at 25 °C | Boiling Point | 34.6°C | |
| Molecular Formula | C12H19N3O5S | Melting Point | -116.3°C | |
| MSDS | USA | Flash Point | <−30 °F | |
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Combined disc methods for the detection of KPC- and/or VIM-positive Klebsiella pneumoniae: improving reliability for the double carbapenemase producers.
Clin. Microbiol. Infect. 19(9) , E412-5, (2013) Klebsiella pneumoniae strains co-producing klebsiella pneumoniae carbapenemase (KPC) and verona integron-encoded metallo-beta-lactamase (VIM) are frequently isolated in Greece and have also occurred in other European countries. Conventional combined disc test... |
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inh... |
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Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.
J. Antimicrob. Chemother. 70 , 1434-42, (2015) Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize colistin combinations against Pseudomonas aeruginosa by pro... |
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Identification of capsular types in carbapenem-resistant Klebsiella pneumoniae strains by wzc sequencing and implications for capsule depolymerase treatment.
Antimicrob. Agents Chemother. 59(2) , 1038-47, (2015) Klebsiella pneumoniae is an important human pathogen associated with a variety of diseases, and the prevalence of multidrug-resistant K. pneumoniae (MDRKP) is rapidly increasing. Here we determined the capsular types of 85 carbapenem-resistant K. pneumoniae (... |
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Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa.
J. Antimicrob. Chemother. 68(10) , 2286-90, (2013) MK-7655 is a novel inhibitor of class A and C β-lactamases. We investigated its potential to protect imipenem.Chequerboard MICs were determined by CLSI agar dilution: (i) for Enterobacteriaceae with carbapenemases; (ii) for Enterobacteriaceae with carbapenem ... |
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Imipenem heteroresistance: high prevalence among Enterobacteriaceae Klebsiella pneumoniae carbapenemase producers.
J. Med. Microbiol. 64(Pt 1) , 124-6, (2015)
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Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
Acta Crystallogr. D Biol. Crystallogr. 69(Pt 9) , 1697-706, (2013) The modelling of peptidoglycan is responsible for key cellular processes in Mycobacterium tuberculosis such as cell growth, division and resuscitation from dormancy. The structure of M. tuberculosis peptidoglycan is atypical since it contains a majority of 3,... |
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Risk factors and outcome analysis of acinetobacter baumannii complex bacteremia in critical patients.
Crit. Care Med. 42(5) , 1081-8, (2014) Acinetobacter baumannii complex bacteremia has been identified increasingly in critical patients admitted in ICUs. Notably, A. baumannii complex bacteremia has a high mortality rate, yet the risk factors associated with mortality remain unclear and controvers... |
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Antimicrobial susceptibility of animal and human isolates of Clostridium difficile by broth microdilution.
J. Med. Microbiol. 62(Pt 9) , 1478-85, (2013) A total of 188 human (n = 92) and animal (n = 96) isolates of Clostridium difficile of different PCR ribotypes were screened for susceptibility to 30 antimicrobials using broth microdilution. When comparing the prevalence of antimicrobial resistance, the isol... |
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A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China.
J. Med. Microbiol. 62(Pt 9) , 1343-9, (2013) The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, t... |