N,O-Didansyl-L-tyrosine cyclohexylammonium salt
N,O-Didansyl-L-tyrosine cyclohexylammonium salt structure
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Common Name | N,O-Didansyl-L-tyrosine cyclohexylammonium salt | ||
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| CAS Number | 102783-47-1 | Molecular Weight | 746.93500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H46N4O7S2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
Chem. Biol. 8 , 981-995, (2001) Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inhibitors of an essential enzyme, thymidylate synthase (TS), ... |
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Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.
J. Med. Chem. 48 , 913-916, (2005) N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a submicromolar inhibitor of Lactobacillus casei TS (LcTS), ... |
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Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.
ChemBioChem. 9 , 779-790, (2008) The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets for functional studies and drug discovery. Thymidylate synth... |