N,O-二丹磺酰基-L-酪氨酸环己基铵盐
N,O-二丹磺酰基-L-酪氨酸环己基铵盐结构式
|
常用名 | N,O-二丹磺酰基-L-酪氨酸环己基铵盐 | 英文名 | N,O-Didansyl-L-tyrosine cyclohexylammonium salt |
|---|---|---|---|---|
| CAS号 | 102783-47-1 | 分子量 | 746.93500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C39H46N4O7S2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
|
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
Chem. Biol. 8 , 981-995, (2001) Protein plasticity in response to ligand binding abrogates the notion of a rigid receptor site. Thus, computational docking alone misses important prospective drug design leads. Bacterial-specific inhibitors of an essential enzyme, thymidylate synthase (TS), ... |
|
|
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.
J. Med. Chem. 48 , 913-916, (2005) N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase. The N-dansyl structure modulation led to a submicromolar inhibitor of Lactobacillus casei TS (LcTS), ... |
|
|
Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.
ChemBioChem. 9 , 779-790, (2008) The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication are important targets for functional studies and drug discovery. Thymidylate synth... |