Bromazepam
Bromazepam structure
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Common Name | Bromazepam | ||
|---|---|---|---|---|
| CAS Number | 1812-30-2 | Molecular Weight | 316.153 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 500.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H10BrN3O | Melting Point | 237-238.5ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 256.7±32.9 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples.
J. Pharm. Biomed. Anal. 100 , 28-32, (2014) A simple yet highly efficient pretreatment method called solid-phase dispersive extraction (SPDE) was developed and used in combination with liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for the analysis of benzodiazepines (BZPs) in serum... |
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Application of direct-infusion ESI-MS/MS for toxicological screening.
Bioanalysis 6(15) , 2043-55, (2014) Direct-infusion ESI-MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, foll... |
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Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations.
J. Anal. Toxicol. 32(9) , 782-6, (2008) Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does no... |
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Environmental occurrence, fate and transformation of benzodiazepines in water treatment.
Water Res. 46(2) , 355-68, (2012) Benzodiazepine derivatives are prescribed in large quantities globally and are potentially new emerging environmental contaminants. Unfortunately, a dearth of data exists concerning occurrence, persistence and fate in the environment. This paper redresses thi... |
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Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse.
Fundam. Clin. Pharmacol. 28(6) , 681-9, (2014) Buprenorphine (BPN) is widely used as a substitution treatment for opioid addiction. Some cases of abuse and misuse, especially associated with various benzodiazepines (BZDs), have been described, and a previous study has shown that BZDs increase the sedative... |
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Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry.
Anal. Bioanal. Chem 402(8) , 2555-64, (2012) The liquid chromatography-mass spectrometry (LC-MS) analysis of complex samples such as biological fluid extracts is widespread when searching for new biomarkers as in metabolomics. The success of this hyphenation resides in the orthogonality of both separati... |
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Segmental hair analysis can demonstrate external contamination in postmortem cases.
Forensic Sci. Int. 215(1-3) , 73-6, (2012) Excluding laboratory mistakes, a false positive hair result can be observed in case of contamination from environmental pollution (external contamination) or after drug incorporation into the hair from the individual body fluids, such as sweat or putrefactive... |
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Pharmacoepidemiological characterization of psychotropic drugs consumption using a latent class analysis.
Int. Clin. Psychopharmacol. 26(1) , 54-62, (2011) France has one of the highest recorded rates of psychotropic use of drugs compared with other European countries, especially for anxiolytics, hypnotics and antidepressants. The aim of this study was to characterize the use of three psychotropic drugs among th... |