Journal of Analytical Toxicology 2008-01-01

Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations.

P-Rop Pos Pok, Djamel Haddouche, Michel Mauras, Erika Kuhlmann, Joëlle Burle, Thierry Salmon, Emilie Berland, P-Emmanuel Coiffait, Alain Viala

Index: J. Anal. Toxicol. 32(9) , 782-6, (2008)

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Abstract

Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does not differ from the corresponding peripheral blood concentration (587 ng/mL for nordiazepam and 883 ng/mL for bromazepam). The mean ratios for the heart and peripheral blood concentrations were 0.95 for nordiazepam and 0.86 for bromazepam. No postmortem redistribution was observed for these two benzodiazepines. The authors thus suggest that corresponding heart blood can be proposed in the quantitative analysis of these drugs when peripheral blood is unavailable. The present study also shows the stability of the two drugs after a year of storage.