BIS(7)-TACRINE
BIS(7)-TACRINE structure
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Common Name | BIS(7)-TACRINE | ||
|---|---|---|---|---|
| CAS Number | 224445-12-9 | Molecular Weight | 565.619 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H42Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
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Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.
J. Chem. Soc. Perkin Trans. I , 171, (1997)
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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.
J. Biol. Chem. 271 , 23646, (1996) We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand docking with target proteins: 1) identify low affinity sites n... |
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