BIS(7)-TACRINE

Modify Date: 2024-01-10 18:35:25

BIS(7)-TACRINE structure	Common Name	BIS(7)-TACRINE
	CAS Number	224445-12-9	Molecular Weight	565.619
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₂Cl₂N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BIS(7)-TACRINE

Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3].

Name	N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine,dihydrochloride
Synonym	More Synonyms

Description	Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32. [2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800. [3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> iGluR

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> AChE

References

[1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32.

[2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800.

[3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509.

Molecular Formula	C₃₃H₄₂Cl₂N₄
Molecular Weight	565.619
Exact Mass	564.278625
PSA	49.84000
LogP	9.76510

Hazard Codes	T: Toxic;
Risk Phrases	25-36/37/38
Safety Phrases	26-36-45
RIDADR	UN 2811 6.1/PG 3

Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.

J. Chem. Soc. Perkin Trans. I , 171, (1997)

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.

J. Biol. Chem. 271 , 23646, (1996)

We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand doc...

N,N'-Di(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine dihydrochloride

9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride

Tacrine-Based Inhibitor 2f

heptylene-bis(tacrine) dihydrochloride heptylene-bis(THA) dihydrochloride

1,7-Heptanediamine, N,N-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2)

DC Chemicals Limited
China
Product Name: Bis(7)-tacrine dihydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BIS(7)-TACRINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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