1,2-Ethanedithiol

1,2-Ethanedithiol Structure
1,2-Ethanedithiol structure
Common Name 1,2-Ethanedithiol
CAS Number 540-63-6 Molecular Weight 94.199
Density 1.1±0.1 g/cm3 Boiling Point 144.3±13.0 °C at 760 mmHg
Molecular Formula C2H6S2 Melting Point −41 °C(lit.)
MSDS Chinese USA Flash Point 44.4±0.0 °C
Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger

Humanin Derivatives Inhibit Necrotic Cell Death in Neurons.

Mol. Med. 21 , 505-14, (2015)

Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer's disease. Herein, we identify a novel function of the humanin-derivative AGA(C8R)-HNG17 (namely, protection against cellular necrosis). Necrosis is on...

Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.

ChemMedChem 9(11) , 2463-74, (2014)

Pancreatic polypeptide (PP) is a satiety-inducing gut hormone targeting predominantly the Y4 receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP-based ligands have already been reported to exert prolonged satiety-inducing eff...

Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations.

J. Gen. Virol. 95(Pt 2) , 363-72, (2014)

Non-structural 5A protein (NS5A) has emerged as an important pharmacological target for hepatitis C virus (HCV). However, little is known about the conformation of NS5A intracellularly or how NS5A inhibitors achieve the picomolar (pM) inhibition of virus repl...

Mimicking and Understanding the Agglutination Effect of the Antimicrobial Peptide Thanatin Using Model Phospholipid Vesicles.

Biochemistry 54 , 3932-41, (2015)

Thanatin is a cationic 21-residue antimicrobial and antifongical peptide found in the spined soldier bug Podisus maculiventris. It is believed that it does not permeabilize membranes but rather induces the agglutination of bacteria and inhibits cellular respi...

A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.

Soft Matter 11(2) , 414-21, (2014)

The peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH. Linear rheology measurements demonstrate that the gel shows a dominating elastic response over a large frequency in...

Nano-colloid printing of functionalized PLA-b-PEO copolymers: tailoring the surface pattern of adhesive motif and its effect on cell attachment.

Physiol. Res. 64 Suppl 1 , S61-73, (2015)

In this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from selective...

Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins.

Nat. Protoc. 3(9) , 1527-34, (2008)

The membrane-permeant fluorogenic biarsenicals FlAsH-EDT(2) and ReAsH-EDT(2) can be prepared in good yields by a straightforward two-step procedure from the inexpensive precursor dyes fluorescein and resorufin, respectively. Handling of toxic reagents such as...

Energy level modification in lead sulfide quantum dot thin films through ligand exchange.

ACS Nano 8(6) , 5863-72, (2014)

The electronic properties of colloidal quantum dots (QDs) are critically dependent on both QD size and surface chemistry. Modification of quantum confinement provides control of the QD bandgap, while ligand-induced surface dipoles present a hitherto underutil...

Tumor accumulation of protein kinase-responsive gene carrier/DNA polyplex stabilized by alkanethiol for intravenous injection.

J. Biomater. Sci. Polym. Ed. 26 , 657-68, (2015)

We synthesized polymeric gene carriers consisting of poly-L-lysine (PLL) main chain modified both with substrate peptide for protein kinase Cα (PKCα) and alkanethiol (pentadecanethiol). Due to the grafted substrate peptide, the polyplex prepared from these ca...

Structure-function relationships in histidine-rich antimicrobial peptides from Atlantic cod.

Biochim. Biophys. Acta 1848 , 1451-61, (2015)

Gad-1 and Gad-2 are antimicrobial peptide (AMP) sequences encoded by paralogous genes. They are rich in histidine, which suggests that their activity might be pH-dependent. We examined their structure-function relationships with a view to learning how to impr...