Boc-L-phenylalanine
Boc-L-phenylalanine structure
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Common Name | Boc-L-phenylalanine | ||
|---|---|---|---|---|
| CAS Number | 13734-34-4 | Molecular Weight | 265.31 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 426.6±38.0 °C at 760 mmHg | |
| Molecular Formula | C14H19NO4 | Melting Point | 85-87 °C(lit.) | |
| MSDS | USA | Flash Point | 211.8±26.8 °C | |
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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nat. Chem. Biol. 5 , 45-52, (2009) Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid anal... |
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Investigation of dendriplexes by ion mobility-mass spectrometry.
Molecules 19(12) , 20731-50, (2014) Highly branched polyamidoamine (PAMAM) dendrimers presenting biological activities have been envisaged as non-viral gene delivery vectors. They are known to associate with nucleic acid (DNA) in non-covalent complexes via electrostatic interactions. Although t... |
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NMR spectroscopic detection of chirality and enantiopurity in referenced systems without formation of diastereomers.
Nat. Commun. 4 , 2188, (2013) Enantiomeric excess of chiral compounds is a key parameter that determines their activity or therapeutic action. The current paradigm for rapid measurement of enantiomeric excess using NMR is based on the formation of diastereomeric complexes between the chir... |
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A novel cabazitaxel-loaded polymeric micelle system with superior in vitro stability and long blood circulation time.
J. Biomater. Sci. Polym. Ed. 27 , 626-42, (2016) Cabazitaxel (CTX) is a second-generation semisynthetic taxane that demonstrates antitumor activity superior to docetaxel. However, the low aqueous solubility of CTX has hampered its use as a therapeutic agent. In this work, CTX-loaded N-t-butoxycarbonyl-L-phe... |
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Nanofibrous spongy microspheres enhance odontogenic differentiation of human dental pulp stem cells.
Adv. Healthc. Mater. 4 , 1993-2000, (2015) Dentin regeneration is challenging due to its complicated anatomical structure and the shortage of odontoblasts. In this study, a novel injectable cell carrier, nanofibrous spongy microspheres (NF-SMS), is developed for dentin regeneration. Biodegradable and ... |
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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs.
J. Nucleic Acids 2011 , 652702, (2011) Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations and ... |
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Topical iontophoretic delivery of ionizable, biolabile aciclovir prodrugs: A rational approach to improve cutaneous bioavailability.
Eur. J. Pharm. Biopharm. 99 , 103-13, (2016) The objective was to investigate the topical iontophoretic delivery of a series of amino acid ester prodrugs of aciclovir (ACV-X, where ACV=aciclovir and X=Arg, Gly, Ile, Phe, Trp and Val) as a means to enhance cutaneous delivery of ACV. The newly synthesized... |
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Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.
Mol. Pharm. 5 , 717-27, (2008) Dipeptide monoester prodrugs of floxuridine were synthesized, and their chemical stability in buffers, resistance to glycosidic bond metabolism, affinity for PEPT1, enzymatic activation and permeability in cancer cells were determined and compared to those of... |
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Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine.
Arch. Pharm. Res. 37 , 142-8, (2013) Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by grafting L-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed th... |
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Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility.
Eur. J. Med. Chem. 46 , 704-11, (2011) The peptides of elastin sequences chosen for the present study included tetrapeptides, pentapeptides and tricosapeptides (30 amino acids), synthesized by classical solution phase method and conjugated to [3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole]. The struc... |