acetaminophen glucuronide
acetaminophen glucuronide structure
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Common Name | acetaminophen glucuronide | ||
|---|---|---|---|---|
| CAS Number | 16110-10-4 | Molecular Weight | 330.30500 | |
| Density | 1.61g/cm3 | Boiling Point | 697.4ºC at 760mmHg | |
| Molecular Formula | C14H14D3NO8 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 375.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Clin. Exp. Pharmacol. Physiol. 36(1) , 35-42, (2009) 1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in ... |
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Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.
Bioanalysis 4(12) , 1429-43, (2012) In support of a pilot clinical trial using acetaminophen as the model compound to assess dried blood spot (DBS) sampling as the method for clinical pharmacokinetic sample collection, a novel sensitive LC-MS/MS method was developed and validated for the simult... |
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Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Int. J. Clin. Pharmacol. Ther. 45(9) , 496-503, (2007) Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations, a small fraction of the drug undergoes oxidative metabolism via cytochrome P450 forming the hepatot... |
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Pharmacokinetics of intravenous paracetamol in elderly patients.
Clin. Pharmacokinet. 50(2) , 121-9, (2011) Intravenous paracetamol (N-acetyl-paraminophenol, acetaminophen) is a widely used nonopioid analgesic which has become popular in the treatment of pain in many patient groups, including the elderly. Although intravenous paracetamol has been studied widely in ... |
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Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.
Br. J. Clin. Pharmacol. 75(3) , 850-60, (2013) A recent report on intravenous (i.v.) paracetamol pharmacokinetics (PK) showed a higher total clearance in women at delivery compared with non-pregnant women. To describe the paracetamol metabolic and elimination routes involved in this increase in clearance,... |
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Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine.
Anal. Biochem. 374(1) , 106-11, (2008) An HPLC-MS/MS method has been developed for the selective quantitative analysis of paracetamol and its two major metabolites. The use of tandem MS enabled the detection and quantitation of metabolites in small sample sizes with high sensitivity and selectivit... |
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Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Toxicol. Sci. 109 , 31-40, (2009) Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high doses. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that mitigates electrophilic stress from AA by inducing genes, such as NAD(P)H:quinone ... |
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Investigating paracetamol pharmacokinetics using venous and capillary blood and saliva sampling.
J. Pharm. Pharmacol. 64(5) , 705-11, (2012) The aim of this study was to develop, validate and apply a high performance liquid chromatography (HPLC) assay for analysis of paracetamol, paracetamol glucuronide and paracetamol sulfate in plasma (venous and capillary) and saliva to study paracetamol pharma... |
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The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
J. Gerontol. A. Biol. Sci. Med. Sci. 69(4) , 387-97, (2014) We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen. Young and old male Fischer 344 rats were treated with 800 mg/kg acetaminophen (young n = 8, old n = 5) or saline (young n... |
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Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: application to a clinical pharmacokinetic study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 893-894 , 162-7, (2012) A specific, sensitive and rapid method based on high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) was developed for the simultaneous determination of paracetamol (APAP) and its glucuronide conjugate (PG) in human plasma a... |