DL-O-Phosphoserine
DL-O-Phosphoserine structure
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Common Name | DL-O-Phosphoserine | ||
|---|---|---|---|---|
| CAS Number | 17885-08-4 | Molecular Weight | 185.07200 | |
| Density | 1.809g/cm3 | Boiling Point | 475.4ºC at 760mmHg | |
| Molecular Formula | C3H8NO6P | Melting Point | 190ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 241.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.
Anal. Chem. 81(10) , 3919-32, (2009) We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass s... |
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Catalytic DNA with phosphatase activity.
Proc. Natl. Acad. Sci. U. S. A. 110(14) , 5315-20, (2013) Catalytic DNA sequences (deoxyribozymes, DNA enzymes, or DNAzymes) have been identified by in vitro selection for various catalytic activities. Expanding the limits of DNA catalysis is an important fundamental objective and may facilitate practical utility of... |
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IGF-1 alleviates NMDA-induced excitotoxicity in cultured hippocampal neurons against autophagy via the NR2B/PI3K-AKT-mTOR pathway.
J. Cell Physiol. 229(11) , 1618-29, (2014) Insulin-like growth factor-1 (IGF-1) is a brain-specific multifunctional protein involved in neuronal polarity and axonal guidance. Mature IGF-1 triggers three enzymes, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and phospho... |
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Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorg. Med. Chem. Lett. 15 , 1683-6, (2005) The interaction of five human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, that is, hCA I, II, IV, V, and IX with a small library of phosphonic acids/organic phosphates, including methylphosphonic acid, MPA; phenylphosphonic acid, PPA; N-(phosphonoacetyl)-L... |
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Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody.
Proc. Natl. Acad. Sci. U. S. A. 111(17) , 6269-74, (2014) Signal transducer and activator of transcription 3 (STAT3) is a multifunctional protein that participates in signaling pathways initiated by various growth factors and cytokines. It exists in multiple forms including those phosphorylated on Tyr(705) (pYSTAT3)... |
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Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.
Autophagy 9(2) , 208-19, (2013) Endoplasmic reticulum (ER) stress induces both autophagy and apoptosis yet the molecular mechanisms and pathways underlying the regulation of these two cellular processes in cells undergoing ER stress remain less clear. We report here that eukaryotic elongati... |
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Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety.
PLoS ONE 8(3) , e57700, (2013) Neonatal exposure of rodents to an immune challenge alters a variety of behavioural and physiological parameters in adulthood. In particular, neonatal lipopolysaccharide (LPS; 0.05 mg/kg, i.p.) exposure produces robust increases in anxiety-like behaviour, acc... |
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The Streptococcus thermophilus protein Wzh functions as a phosphotyrosine phosphatase.
Can. J. Microbiol. 59(6) , 391-8, (2013) Amino acid residues that are important for metal binding and catalysis in Gram-positive phosphotyrosine phosphatases were identified in the Wzh protein of Streptococcus thermophilus MR-1C by using sequence comparisons. A His-tagged fusion Wzh protein was puri... |
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TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
J. Biomed. Nanotechnol. 10(7) , 1217-30, (2014) TET1 protein is reported to suppress cancer invasion and metastasis in prostate and breast cancer while EZH2, a polycomb group protein, has been identified as an oncogene in many types of cancers including gastric cancer. Here we report that there is an inver... |
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The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
Genes Dev. 27(11) , 1299-312, (2013) Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle wasting holds the potential of identifying molecular pathways that constitute possible drug targets. Here, we report that the methyltransferase SMYD3 modulates myos... |