morphine sulfate
morphine sulfate structure
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Common Name | morphine sulfate | ||
|---|---|---|---|---|
| CAS Number | 64-31-3 | Molecular Weight | 383.41600 | |
| Density | N/A | Boiling Point | 476.2ºC at 760 mmHg | |
| Molecular Formula | C17H21NO7S | Melting Point | 255ºC | |
| MSDS | N/A | Flash Point | 241.8ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Catalytic enantioselective synthesis of quaternary carbon stereocentres.
Nature 516(7530) , 181-91, (2014) Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoi... |
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Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.
J. Pharmacol. Exp. Ther. 351(3) , 576-84, (2014) Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are lacking. This deficiency is due in part to challenges unique... |
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Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.
Br. J. Anaesth. 113(6) , 964-9, (2014) Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery. We thus aimed to assess the absorption and safety of enterally administered clonidine in this setting.Sixteen infants ... |
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Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Life Sci. 92(23) , 1138-44, (2013) In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analge... |
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Hypernociceptive responses following the intratibial inoculation of RM1 prostate cancer cells in mice.
Prostate 75(1) , 70-83, (2015) Pain due to bone metastases of prostatic origin is a relevant clinical issue. We study here the nociceptive responses obtained in mice receiving the intratibial inoculation of RM1 prostate cancer cells.10(2) -10(5) RM1 cells were inoculated to C57BL/6 mice an... |
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Label-free monitoring of μ-opioid receptor-mediated signaling.
Mol. Pharmacol. 86(2) , 138-49, (2014) In this study, we used a combination of traditional signaling investigation approaches, bioluminescence resonance energy transfer (BRET) biosensors, and the label-free approach surface plasmon resonance (SPR) spectroscopy to monitor the signaling cascades of ... |
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Activation of TRPM7 channels by small molecules under physiological conditions.
Pflugers Arch. 466(12) , 2177-89, (2014) Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a cation channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and regulates key cellular processes such as Mg(2+) homeostasis, motility, and prolife... |
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TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
J. Neurosci. 34(15) , 5385-95, (2014) Transforming growth factor-β1 (TGF-β1) protects against neuroinflammatory events underlying neuropathic pain. TGF-β signaling enhancement is a phenotypic characteristic of mice lacking the TGF-β pseudoreceptor BAMBI (BMP and activin membrane-bound inhibitor),... |
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Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice.
J. Ethnopharmacol. 161 , 82-5, (2015) Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including abdominal pain, arthritis and inflammation. This study was conducted to evaluate the antinociceptive effect of ethanol... |
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Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.
Behav. Pharmacol. 26(3) , 304-14, (2015) Cannabinoid and opioid agonists can display overlapping behavioral effects and the combination of these agonists is known to produce enhanced antinociception in several rodent models of acute and chronic pain. The present study investigated the antinociceptiv... |