Mesaconic acid
Mesaconic acid structure
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Common Name | Mesaconic acid | ||
|---|---|---|---|---|
| CAS Number | 498-24-8 | Molecular Weight | 130.09900 | |
| Density | 1.387 g/cm3 | Boiling Point | 336.6ºC at 760 mmHg | |
| Molecular Formula | C5H6O4 | Melting Point | 200-202ºC | |
| MSDS | Chinese USA | Flash Point | 171.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes.
J. Pharmacol. Exp. Ther. 352(1) , 90-7, (2015) Monomethylfumarate (MMF) is thought to be the bioactive ingredient of the drug Fumaderm (Biogen Idec, Cambridge, MA), licensed in Germany since 1994 for the treatment of moderate-to-severe psoriasis. Psoriasis is a common inflammatory hyperproliferative skin ... |
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In vitro pharmacokinetics of anti-psoriatic fumaric acid esters.
BMC Pharmacol. 4 , 22, (2004) Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use. These tablets consist of dimethylfumarate (DMF) and salts of monoethylfumarate (ME... |
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The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist.
Biochem. Biophys. Res. Commun. 375(4) , 562-5, (2008) Nicotinic acid has been used for several decades to treat dyslipidemia. In mice, the lipid-lowing effect of nicotinic acid is mediated by the Gi coupled receptor PUMA-G. In humans, high (GPR109A) and low (GPR109B) affinity nicotinic acid receptors have been c... |
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A new antigen retrieval technique for human brain tissue.
PLoS ONE 3(10) , e3378, (2008) Immunohistochemical staining of tissues is a powerful tool used to delineate the presence or absence of an antigen. During the last 30 years, antigen visualization in human brain tissue has been significantly limited by the masking effect of fixatives. In the... |
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Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid.
J. Neurol. 258(8) , 1489-93, (2011) We report a case of a patient with a rapidly progressive dementing illness and gait disturbance, in whom initial screening demonstrated a high methylmalonic acid level only, suggestive of a functional vitamin B(12) deficiency. Despite B(12) replacement therap... |
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Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction.
Biochem. J. 367(Pt 1) , 77-85, (2002) A series of fumarate analogues has been used to explore the molecular mechanism of the activation of dopamine beta-mono-oxygenase by fumarate. Mesaconic acid (MA) and trans -glutaconic acid (TGA) both activate the enzyme at low concentrations, similar to fuma... |
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Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate.
FEBS Lett. 580(6) , 1677-80, (2006) The soluble fumarate reductase (FR) from Shewanella frigidimarina can catalyse the reduction of 2-methylfumarate with a k(cat) of 9.0 s(-1) and a K(M) of 32 microM. This produces the chiral molecule 2-methylsuccinate. Here, we present the structure of FR to a... |
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Urinary methylmalonic acid in patients with acute myocardial infarction.
Med. Princ. Pract. 18(3) , 217-22, (2009) To investigate urinary methylmalonic acid (uMMA) levels and their relationship with markers of myocyte necrosis and inflammation in patients with acute myocardial infarction (AMI).The study participants consisted of 80 consecutive patients with AMI and 72 age... |
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Cytokine secretion pattern in treatment of lymphocytes of multiple sclerosis patients with fumaric acid esters.
Immunol. Invest. 40(6) , 581-96, (2011) The present study was performed to investigate the effects of dimethylfumarate (DMF) and methylhydrogen fumarate (MHF) on the cytokine pattern of peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. The PBMCs from patients and healt... |
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Synthesis, characterization and reactivity ratio study of poly(di(tri-n-butyltin) citraconate-co-N-vinylimidazole).
Molecules 15(7) , 4750-6, (2010) The organotin monomer di(tri-n-butyltin) citraconate (DTBTC, I) was synthesized. Subsequently this monomer was copolymerized with N-vinylimidazole (VI) using a free radical technique. The overall conversion was kept low (< or = 14% wt/wt) for all studied samp... |