Alsterpaullone
Alsterpaullone structure
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Common Name | Alsterpaullone | ||
|---|---|---|---|---|
| CAS Number | 237430-03-4 | Molecular Weight | 293.277 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 651.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H11N3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 347.8±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.
J. Med. Chem. 42 , 2909, (1999) The paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. To investigate structure-activity relationships and to develop paullones with antitumor activity, derivatives of the lead structure kenpaullone (9-bromo-7,12-dih... |
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Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
Int. J. Neuropsychopharmacol. 14 , 1051-67, (2011) There is a growing body of evidence suggesting that animal models can be developed to probe the specific domains of bipolar disorder (BD) using the endophenotype approach. Here we tested clinically active antimanic drugs to validate amphetamine-induced hypera... |
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Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis.
Dev. Dyn. 240 , 2673-9, (2011) Although regeneration is widespread among metazoa, the molecular mechanisms have been studied in only a handful of taxa. Of these taxa, fewer still are amenable to studies of embryogenesis. Our understanding of the evolution of regeneration, and its relation ... |
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Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.
Neurotox. Res. 21 , 309-16, (2012) In the central nervous system, members of the Src family of tyrosine kinases (SFKs) are widely expressed and are abundant in neurons. The purpose of this study is to examine whether glycogen synthase-3 (GSK-3) is involved in SFK inhibitor-induced apoptosis. P... |