237430-03-4

237430-03-4 structure

Name: Alsterpaullone
Chemical Name: Alsterpaullone
CAS Number: 237430-03-4
Molecular Formula: C₁₆H₁₁N₃O₃
Molecular Weight: 293.277
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2018-04-05 08:00:00
Modify Date: 2024-01-12 18:18:24
Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent cyclin-dependent kinases (CDK) inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to glycogen synthase kinase-3 alpha/beta (GSK-3alpha/GSK-3beta) with an IC50 of 4 nM, with antitumor activity and potential for the treatment of neurodegenerative and proliferative disorders[1].

Name	Alsterpaullone
Synonyms	9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one Indolo[3,2-d][1]benzazepin-6(5H)-one, 7,12-dihydro-9-nitro- 9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one

Description	Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent cyclin-dependent kinases (CDK) inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to glycogen synthase kinase-3 alpha/beta (GSK-3alpha/GSK-3beta) with an IC50 of 4 nM, with antitumor activity and potential for the treatment of neurodegenerative and proliferative disorders[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	Cdk1/cyclin B:35 nM (IC50) cdk2/cyclin A:15 nM (IC50) CDK2/Cyc E:200 nM (IC50) CDK5/p35:40 nM (IC50) GSK-3α:4 (IC50) GSK-3β:4 nM (IC50)
References	[1]. Leost M, et al. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem. 2000 Oct;267(19):5983-94. [2]. Lahusen T, et al. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinog. 2003 Apr;36(4):183-94.

Density	1.5±0.1 g/cm3
Boiling Point	651.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₁N₃O₃
Molecular Weight	293.277
Flash Point	347.8±28.7 °C
Exact Mass	293.080048
PSA	90.71000
LogP	3.55
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.738

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2933990090

16511-38-9

636-99-7

~32%

237430-03-4

Literature: Zaharevitz, Daniel W.; Gussio, Rick P.; Jalluri, Ravi K.; Sausville, Edward A.; Kunick, Conrad; Meijer, Laurent Patent: US2002/42412 A1, 2002 ;

Precursor 2
16511-38-9 636-99-7
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%