2-Piperidone
2-Piperidone structure
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Common Name | 2-Piperidone | ||
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| CAS Number | 675-20-7 | Molecular Weight | 99.131 | |
| Density | 1.073 | Boiling Point | 256-262 ºC | |
| Molecular Formula | C5H9NO | Melting Point | 38-40 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 147 ºC | |
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The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica.
Chemistry 15(7) , 1597-603, (2009) Escapin is an L-amino acid oxidase in the ink of a marine snail, the sea hare Aplysia californica, which oxidizes L-lysine (1) to produce a mixture of chemicals which is antipredatory and antimicrobial. The goal of our study was to determine the identity and ... |
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Biosynthesis of 5-aminopentanoic acid and 2-piperidone from cadaverine and 1-piperideine in mouse.
J. Neurochem. 43(6) , 1631-4, (1984) 1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1-pi... |
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Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones.
J. Org. Chem. 66(21) , 6852-6, (2001) Catalytic asymmetric synthesis of 4-aryl-2-piperidinones was realized for the first time by asymmetric 1,4-addition of arylboron reagents to 5,6-dihydro-2(1H)-pyridinones in the presence of a chiral bisphosphine-rhodium catalyst. In the reaction introducing 4... |
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Palladium-catalyzed asymmetric 6-endo cyclization of dienamides with substituent-driven activation.
Org. Lett. 14(9) , 2326-9, (2012) Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents. |
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Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
J. Med. Chem. 40(1) , 44-9, (1997) A series of 3-substituted 2-piperidinone (delta-valerolactam) and hexahydro-2H-azepin-2-one (epsilon-caprolactam) derivatives were prepared and evaluated as anticonvulsants in mice. In the 2-piperidinone series, 3,3-diethyl compound 7b is the most effective a... |
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Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives.
Il Farmaco 52(10) , 603-8, (1997) The synthesis of a series of 2-amino-4-hydroxy-delta-valerolactam derivatives is described (compounds 4 to 10). These compounds showed a high anthelmintic in vitro activity against the Nippostrongylus brasiliensis model. |
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Slow photoelectron spectroscopy of δ-valerolactam and its dimer.
ChemPhysChem 12(10) , 1822-32, (2011) We studied the single-photon ionization of gas-phase δ-valerolactam (piperidin-2-one) and of its dimer using vacuum-ultraviolet (VUV) synchrotron radiation coupled to a velocity map imaging electron/ion coincidence spectrometer. The slow photoelectron spectru... |
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Asymmetric synthesis of gamma-keto-delta-lactam derivatives: application to the synthesis of a conformationally constrained surrogate of Ala-Ser dipeptide.
J. Org. Chem. 66(23) , 7915-8, (2001)
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Excited state tautomerization of 7-azaindole in a 1:1 complex with δ-valerolactam: a comparative study with the homodimer.
J. Phys. Chem. A 116(40) , 9888-96, (2012) A comparative analysis for relative stability between normal and tautomeric forms in the excited electronic states of 7-azaindole···δ-valerolactam 1:1 complex and 7-azaindole homodimer has been presented. The tautomeric configuration of the complex is estimat... |