Il Farmaco 1997-10-01

Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives.

S Gordon, L Costa, M Incerti, E Manta, J Saldaña, L Domínguez, R Mariezcurrena, L Suescun

Index: Il Farmaco 52(10) , 603-8, (1997)

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Abstract

The synthesis of a series of 2-amino-4-hydroxy-delta-valerolactam derivatives is described (compounds 4 to 10). These compounds showed a high anthelmintic in vitro activity against the Nippostrongylus brasiliensis model.