Organic Letters 2012-05-04

Palladium-catalyzed asymmetric 6-endo cyclization of dienamides with substituent-driven activation.

Hiroshi Tsuchikawa, Yuya Maekawa, Shigeo Katsumura

Index: Org. Lett. 14(9) , 2326-9, (2012)

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Abstract

Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents.