Physcion
Physcion structure
|
Common Name | Physcion | ||
|---|---|---|---|---|
| CAS Number | 521-61-9 | Molecular Weight | 284.26 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 560.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | 196-206°C | |
| MSDS | Chinese USA | Flash Point | 215.4±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015) Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two or more herbs based on the clinical settings and the proper... |
|
|
Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.
Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008) As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2. A... |
|
|
Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats.
Chem. Res. Toxicol. 28 , 1120-32, (2015) Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. Therefore, the present study was designed to identify the key ... |
|
|
The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats.
Eur. J. Drug Metab. Pharmacokinet. 40 , 379-88, (2015) In the study, it was hypothesized that Rhubarb Anthraquinones synergistically enhanced the purgative effect on constipation rat from the direct and indirect pathway at the same time. A validated HPLC method was successfully applied to elucidate the synergism ... |
|
|
Anti-metastatic effects of Rheum Palmatum L. extract in human MDA-MB-231 breast cancer cells.
Environ. Toxicol. Pharmacol. 40 , 30-8, (2015) Rheum palmatum L. (RP) has been widely used in traditional medicine for the treatment of various diseases in Asian countries. The molecular mechanism of its anti-metastasis effect remains elusive. The present study assessed the effect of RP ethanol extract (R... |
|
|
In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.
Antimicrob. Agents Chemother. 51 , 1541-4, (2007) We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our result... |
|
|
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.
J. Med. Chem. 52 , 3784-93, (2009) Anthraquinone derivatives related to the moderately potent, nonselective P2Y(12) receptor antagonist reactive blue 2 (6) have been synthesized and optimized with respect to P2Y(12) receptor affinity. A radioligand binding assay utilizing human blood platelet ... |
|
|
[Studies on the chemical constituents of Kalimeris indica].
Zhong Yao Cai 33(4) , 551-4, (2010) To study the chemical constituents from Kalimeris indica.Compounds were isolated and purified with silica gel and Sephadex LH-20 column chromatography, their structures were determined by using spectroscopic analysis including MS and NMR.Nine compounds were i... |
|
|
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.
Bioorg. Med. Chem. 19 , 631-41, (2011) Cytosolic (TrxR1) and mitochondrial (TrxR2) thioredoxin reductases experience pronounced concentration- and time-dependent inhibition when incubated with the two naphthodianthrones hypericin and pseudohypericin. Pseudohypericin turned out to be a quite strong... |
|
|
[Alkaloids and anthraquinones from branches and leaves of uvaria kurzii].
Zhongguo Zhong Yao Za Zhi 36(9) , 1190-2, (2011) To investigate the chemical constituents of the branches and leaves of Uvaria kurzii.The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicoche... |