Amrinone
Amrinone structure
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Common Name | Amrinone | ||
|---|---|---|---|---|
| CAS Number | 60719-84-8 | Molecular Weight | 187.198 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 451.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C10H9N3O | Melting Point | 294-297ºC | |
| MSDS | Chinese USA | Flash Point | 226.9±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.
Ann. Surg. 251(4) , 780; author reply 780, (2010)
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Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.
Br. J. Pharmacol. 98 , 291-301, (1999) 1. The chronotropic and inotropic effects of amrinone, carbazeran and 3-isobutyl-1-methyl xanthine (IBMX) were examined in isolated preparations of papillary muscle and right atria from rabbit heart. The effects of the drugs on cardiac phosphodiesterase and c... |
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Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents.
J. Enzyme Inhib. Med. Chem. 24(4) , 918-29, (2009) Selective PDE3 inhibitors improve cardiac contractility and may be used in congestive heart failure. However, their proarrhythmic potential is the most important side effect. In this research we designed, synthesized and evaluated the potential cardiotonic ac... |
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Mechanisms of increased right and left ventricular oxygen uptake during inotropic stimulation.
Life Sci. 93(2-3) , 59-63, (2013) Few studies have investigated oxygen supply/demand relations in right ventricle (RV). The current study compared changes in myocardial oxygen uptake (MVO2) and its determinants, myocardial blood flow (MBF) and oxygen extraction (EO2), in RV and left ventricle... |
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Effect of amrinone on mucosal permeability in experimental intestinal ischaemia/reperfusion injury.
ANZ J. Surg. 75(7) , 608-13, (2005) The preventive effect of amrinone on ischaemia/reperfusion (I/R) injury has been shown in the medical literature. The purpose of the present study was to investigate the preventive effect of amrinone on I/R injury of the small bowel of the rat.Thirty-two Wist... |
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Myocardial cyclic AMP augmentation with high-dose PDEIII inhibitor in terminal warm blood cardioplegia.
Ann. Thorac. Cardiovasc. Surg. 15(5) , 311-7, (2009) Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) ... |
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[Amrinone (Wincoram)--a new positive inotropic and vasodilator agent].
Anaesthesist 37(7) , 400-7, (1988) The bipyridine derivative amrinone is a specific phosphodiesterase III blocking agent. In vitro and in vivo studies show a dose-dependent increase in myocardial contractility induced by amrinone. In patients with congestive heart failure, the inotropic and va... |
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[Multicenter study of the hemodynamic action of intravenous amrinone in the treatment of acute congestive cardiac failure].
Ann. Cardiol. Angeiol. (Paris.) 37(8) , 461-5, (1988)
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The role of amrinone in treating heart failure during and after coronary artery surgery supported by cardiopulmonary bypass.
J. Card. Surg. 9(3 Suppl) , 453-8, (1994) Amrinone and dobutamine compare favorably in the treatment of chronic congestive heart failure. There is increasing evidence that amrinone alone or in combination with a catecholamine may be used with considerable success in treating patients who are difficul... |
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The effect of amrinone on liver regeneration in experimental hepatic resection model.
J. Surg. Res. 130(1) , 66-72, (2006) The phosphodiesterase inhibitors (PDEIs) have been proposed to improve hepatic reperfusion injury and hepatosplanchnic circulation, but the effects of these agents on liver regeneration have not been investigated thoroughly. The aim of this study was to inves... |