Diphenylpyraline (hydrochloride)
Diphenylpyraline (hydrochloride) structure
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Common Name | Diphenylpyraline (hydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 132-18-3 | Molecular Weight | 317.85300 | |
| Density | N/A | Boiling Point | 378.7ºC at 760mmHg | |
| Molecular Formula | C19H24ClNO | Melting Point | 203-205ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 111.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A possible approach to the suppression of side effects induced by PGE1.
Prostaglandins Leukot. Essent. Fatty Acids 52(1) , 17-20, (1995) Prostaglandin E1 (PGE1) is known to possess various actions in vivo. Of these actions, the contraction of the ileum and inflammation are undesirable side effects. We previously proposed a hypothesis concerning the receptors for human blood platelet aggregatio... |
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Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry.
Rapid Commun. Mass Spectrom. 20(4) , 537-43, (2006) Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip ... |
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Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward.
Eur. J. Pharmacol. 683(1-3) , 161-5, (2012) Diphenylpyraline hydrochloride (DPP) is an internationally available antihistamine that produces therapeutic antiallergic effects by binding to histamine H₁ receptors. The complete neuropharmacological and behavioral profile of DPP, however, remains uncharact... |
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Effects of H1 antihistamines on canine nasal vascular and airway resistances.
Rhinology 25(2) , 95-100, (1987) The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Dipheny... |
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[Parkinsonism associated with cerebrotendinous xanthomatosis].
Rinsho. Shinkeigaku 30(9) , 978-84, (1990) Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration, ataxic -spa... |
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Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients.
J. Neurol. Sci. 182(2) , 95-7, (2001) A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been ra... |
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[Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age].
Rev. Invest. Clin. 63(4) , 335-43, (2011) Acute respiratory infections are the second leading cause of morbidity in children under 18 years. Several drugs have been used with variable efficacy and safety, trying to reduce the associated symptoms and improve quality of life.To evaluate the efficacy an... |
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Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.
J. Pharm. Biomed. Anal. 24(1) , 25-31, (2000) A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitr... |
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Determination of diphenylpyraline in plasma and urine by high-performance liquid chromatography.
J. Chromatogr. B, Biomed. Appl. 677(2) , 319-23, (1996) A rapid, reliable and specific reversed-phase high-performance liquid chromatographic procedure is described for the determination of diphenylpyraline hydrochloride at nanogram concentrations in plasma and urine. After extraction of the drug with n-pentane-2-... |
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Antimycobacterial activity of diphenylpyraline derivatives.
Eur. J. Med. Chem. 43 , 872-9, (2008) 2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity agai... |