Hemicholinium 3
Hemicholinium 3 structure
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Common Name | Hemicholinium 3 | ||
|---|---|---|---|---|
| CAS Number | 312-45-8 | Molecular Weight | 574.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H34Br2N2O4 | Melting Point | 180 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter.
ACS Chem. Neurosci. 6(3) , 417-27, (2015) The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmac... |
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Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries.
J. Pharmacol. Exp. Ther. 354 , 121-30, (2015) Mild hypothermia causes endothelium-dependent relaxations, which are reduced by the muscarinic receptor antagonist atropine. The present study investigated whether endothelial endogenous acetylcholine contributes to these relaxations. Aortic rings of spontane... |
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Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.
J. Pharmacol. Exp. Ther. 352(3) , 519-28, (2015) Metformin is the frontline therapy for type II diabetes mellitus. The oral bioavailability of metformin is unexpectedly high, between 40 and 60%, given its hydrophilicity and positive charge at all physiologic pH values. Previous studies in Caco-2 cell monola... |
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Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors.
BMC Cancer 15 , 152, (2015) One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms of oncogenic effects of inhaled nicotine. Current ... |
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Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors.
Int. Immunopharmacol. 29 , 36-44, (2015) Although the role of nicotine as a carcinogen is debatable, it is widely accepted that it contributes to cancer by promoting growth and survival of mutated cell clones and protecting them from the chemo- and radiotherapy-induced apoptosis. On the cell membran... |
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Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression.
Int. Immunopharmacol. 29 , 15-20, (2015) Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complication... |
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The acetylcholine signaling network of corneal epithelium and its role in regulation of random and directional migration of corneal epithelial cells.
Invest. Ophthalmol. Vis. Sci. 55(10) , 6921-33, (2014) Because cholinergic drugs are used in ophthalmology and cholinergic stimulation has been shown to facilitate epithelialization of mucocutaneous wounds, we performed a systematic analysis of components of the cholinergic network of human and murine corneal epi... |
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Both neuronal and non-neuronal acetylcholine take part in non-quantal acetylcholine release in the rat atrium.
Life Sci. 91(21-22) , 1023-6, (2012) In mammalian myocardium acetylcholine (ACh), neurotransmitter which strikingly affects the cardiomyocytes, can be released from the neurons both via quantal (vesicular) and nonquantal (non-vesicular) mechanism of secretion. Non-quantal release is continuous, ... |
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Autocrine control of angiogenesis by endogenous acetylcholine in an in vitro model using human endothelial cells: evidence for an autocrine cholinergic system in endothelial cells.
J. Cardiovasc. Pharmacol. 65 , 508-15, (2015) We wanted to elucidate whether acetylcholine as the endogenous ligand at cholinoceptors (ChRs) may have effects on angiogenesis and whether they are transduced through muscarinic or nicotinic ChRs. Human umbilical vein endothelial cells were cultured until co... |
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Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Horm. Metab. Res. 42(4) , 261-7, (2010) Racecadotril is known as an inhibitor of enkephalinase. Increase of plasma insulin by racecadotril has been observed in rats while the mechanism of the action remains obscure. In the present study, intravenous injection of male Wistar rats with racecadotril s... |