RO 20-1724
RO 20-1724 structure
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Common Name | RO 20-1724 | ||
|---|---|---|---|---|
| CAS Number | 29925-17-5 | Molecular Weight | 278.35 | |
| Density | 1.099 g/cm3 | Boiling Point | 483.8ºC at 760 mmHg | |
| Molecular Formula | C15H22N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 246.4ºC | |
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Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.
J. Physiol. 593 , 2955-73, (2015) Long-lasting neuropathic pain has been attributed to elevated neuronal plasticity changes in spinal, peripheral and cortical levels. Here, we found that reduced neuronal plasticity in the ventrolateral periaqueductal grey (vlPAG), a midbrain region important ... |
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Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
BMC Neurosci. 11 , 7, (2010) There is an urgent need of neuronal cell models to be applied to high-throughput screening settings while recapitulating physiological and/or pathological events occurring in the Central Nervous System (CNS). Stem cells offer a great opportunity in this direc... |
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Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
Purinergic Signal. 11 , 519-31, (2015) The A(2B) adenosine receptor (AR) has emerged as a unique member of the AR family with contrasting roles during acute and chronic disease states. We utilized zinc-finger nuclease technology to create A(2B)AR gene (Adora2b)-disrupted rats on the Dahl salt-sens... |
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Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.
Cancer. Immunol. Res. 3 , 506-17, (2015) Immunotherapy is rapidly emerging as a cancer treatment with high potential. Recent clinical trials with anti-CTLA-4 and anti-PD-1/PD-L1 antibodies (mAbs) suggest that targeting multiple immunosuppressive pathways may significantly improve patient survival. T... |
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Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.
Mol. Pharmacol. 87 , 907-15, (2015) The adenosine A2A receptor (A(2A)R) plays a key role in transmembrane signaling mediated by the endogenous agonist adenosine. Here, we describe the crystal structure of human A2AR thermostabilized in an active-like conformation bound to the selective agonist ... |
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Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes.
Neuropharmacology 85 , 499-507, (2014) Methamphetamine (METH) is abused by about 5% of the United States population with approximately 10-15% of human immunodeficiency virus-1 (HIV-1) patients reporting its use. METH abuse accelerates the onset and severity of HIV-associated neurocognitive disorde... |
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Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion.
Cell. Signal. 19(12) , 2507-18, (2007) By activating two distinct classes of effector enzymes, namely Protein Kinases A [PKA] or Exchange Proteins Activated by cAMP [EPAC], the ubiquitous second messenger cAMP selectively coordinates numerous events simultaneously in virtually all cells. Studies f... |
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Cannabinoid receptor 1 ligands revisited: Pharmacological assessment in the ACTOne system.
Anal. Biochem. 498 , 28-Aug, (2016) In vitro cannabinoid pharmacology has evolved over time from simple receptor binding to include [(35)S]GTPγ, β-arrestin, and cAMP assays. Each assay has benefits and drawbacks; however, no single functional system has been used for high-throughput evaluation ... |
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Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study.
Urology 80(4) , 952.e9-14, (2012) To investigate further the potential significance of the cyclic adenosine monophosphate (cAMP) pathway in the control of prostate smooth muscle. The cAMP pathway has been assumed to be an alternative pharmacologic target to treat dysfunctions of the human low... |
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BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function.
J. Pharmacol. Exp. Ther. 349(1) , 56-65, (2014) Elevation of intracellular cAMP and activation of protein kinase A (PKA) lead to activation of large conductance voltage- and Ca(2+)-activated K(+) (BK) channels, thus attenuation of detrusor smooth muscle (DSM) contractility. In this study, we investigated t... |