Levocabastine hydrochloride
Levocabastine hydrochloride structure
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Common Name | Levocabastine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 79547-78-7 | Molecular Weight | 456.98000 | |
| Density | N/A | Boiling Point | 611ºC at 760 mmHg | |
| Molecular Formula | C26H30ClFN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 323.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.
Eur. J. Ophthalmol. 20(5) , 811-8, (2010) To compare the effects of topical antiallergic eyedrops in relieving the signs and symptoms of patients with allergic conjunctival pathology.In this multicenter, single-masked, randomized study, 240 patients with signs and symptoms of allergic conjunctivitis ... |
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Neurotensin decreases high affinity [3H]-ouabain binding to cerebral cortex membranes.
Regul. Pept. 172(1-3) , 35-40, (2011) Previous work from this laboratory showed the ability of neurotensin to inhibit synaptosomal membrane Na(+), K(+)-ATPase activity, the effect being blocked by SR 48692, a non-peptidic antagonist for high affinity neurotensin receptor (NTS1) [López Ordieres an... |
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Neurotensin is a regulator of insulin secretion in pancreatic beta-cells.
Int. J. Biochem. Cell Biol. 42(10) , 1681-8, (2010) Neurotensin (NT) is secreted from neurons and gastrointestinal endocrine cells. We previously reported that the three NT receptors (NTSRs) are expressed in pancreatic islets and beta cell lines on which we observed a protective effect of NT against cytotoxic ... |
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Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.
Eur. J. Neurosci. 34(8) , 1230-40, (2011) Neurotensin (NT) is a neuropeptide involved in the modulation of nociception. We have investigated the actions of NT on cultured postnatal rat spinal cord dorsal horn (DH) neurons. NT induced an inward current associated with a decrease in membrane conductanc... |
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In vivo investigations of neurotensin receptors in adipocytes, hepatocytes and enterocytes of rat.
Ann. Agric. Environ. Med. 18(2) , 433-6, (2011) Atherosclerotic vascular disease is currently the biggest threat and the highest cause of death worldwide, approaching almost 60%.The development of atherosclerosis is affected by ecological factors associated with industry and pollution of the environment. N... |
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Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
Behav. Brain Res. 175(2) , 399-407, (2006) The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain. We investigated whether these effects are mediated by the opioid receptors. In the hot plate test, the NT recep... |
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The effect of a combined therapy with a histamine H1 antagonist and a chemical mediator release inhibitor on allergic conjunctivitis.
Ophthalmologica 222(4) , 232-9, (2008) To evaluate the efficacy of a combined therapy with levocabastine hydrochloride ophthalmic suspension and pemirolast potassium ophthalmic solution compared to single therapy with levocabastine hydrochloride ophthalmic suspension alone.Thirty-two allergic conj... |
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The effect of topical corticosteroids, topical antihistamines, and preservatives on human ciliary beat frequency.
ORL J. Otorhinolaryngol. Relat. Spec. 76(3) , 127-36, (2014) The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF).Prima... |
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[Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist].
Nippon. Yakurigaku Zasshi. 119(3) , 175-84, (2002) Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjuncti... |
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A multicenter randomized double-blind 2-week comparison study of azelastine nasal spray 0.1% versus levocabastine nasal spray 0.05% in patients with moderate-to-severe allergic rhinitis.
ORL J. Otorhinolaryngol. Relat. Spec. 73(5) , 260-5, (2011) To compare the onset of action, efficacy, and safety of azelastine and levocabastine in the treatment of allergic rhinitis.In a multicenter, randomized, double-blind, parallel-group trial, 244 patients with moderate-to-severe allergic rhinitis were randomized... |