Thymine
Thymine structure
|
Common Name | Thymine | ||
|---|---|---|---|---|
| CAS Number | 65-71-4 | Molecular Weight | 126.113 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 403.8±37.0 °C at 760 mmHg | |
| Molecular Formula | C5H6N2O2 | Melting Point | 316 °C | |
| MSDS | Chinese USA | Flash Point | 198.0±26.5 °C | |
|
Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.
MAbs 7(2) , 403-12, (2015) Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the foot-and-m... |
|
|
In vitro investigations on the effect of dermal fibroblasts on keratinocyte responses to ultraviolet B radiation.
Photochem. Photobiol. 90(6) , 1332-9, (2014) Exposure to ultraviolet radiation is closely linked to the development of skin cancers in humans. The ultraviolet B (UVB) radiation wavelength (280-320 nm), in particular, causes DNA damage in epidermal keratinocytes, which are linked to the generation of sig... |
|
|
An amplified electrochemical strategy using DNA-QDs dendrimer superstructure for the detection of thymine DNA glycosylase activity.
Biosens. Bioelectron. 71 , 249-55, (2015) A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA label with the electrochemical method and quantum dots (QDs) tagging. The DNA-QDs dendrimer-like... |
|
|
Preparation and chromatographic evaluation of a newly designed steviol glycoside modified-silica stationary phase in hydrophilic interaction liquid chromatography and reversed phase liquid chromatography.
J. Chromatogr. A. 1388 , 110-8, (2015) A diterpene glycoside compound, rebaudioside A (commonly abbreviated as RA), was immobilized onto porous silica surface through "thiol-ene" click chemistry strategy. The successful immobilization of the RA on the silica support was confirmed by FT-IR and elem... |
|
|
Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.
J. Chromatogr. A. 1356 , 197-210, (2014) Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved understanding of the absorption and intermediary metabolism ... |
|
|
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
J. Pharmacol. Exp. Ther. 351(2) , 359-72, (2014) Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug Administration-approved drug for the cessation of nerve agent-induced SE. Here, we compared the efficacy of DZP w... |
|
|
Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.
Drug Des. Devel. Ther. 9 , 349-417, (2015) Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells usi... |
|
|
Highly hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica: a novel organic phase for high-selectivity hydrophilic interaction chromatography.
Anal. Bioanal. Chem 406(19) , 4585-93, (2014) A new hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica (Sil-VOX(n)) phase was synthesized and applied for the separation of nucleosides and nucleobases in hydrophilic interaction chromatography (HILIC). Polymerization and immobilization onto sil... |
|
|
Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.
J. Chromatogr. A. 1360 , 275-87, (2014) Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study, five... |
|
|
Identification of a pKa-regulating motif stabilizing imidazole-modified double-stranded DNA.
Nucleic Acids Res. 43(1) , 51-62, (2015) The predictable 3D structure of double-stranded DNA renders it ideally suited as a template for the bottom-up design of functionalized nucleic acid-based active sites. We here explore the use of a 14mer DNA duplex as a scaffold for the precise and predictable... |