Thymine

Modify Date: 2024-01-02 20:20:33

Thymine Structure
Thymine structure
 Common Name Thymine
CAS Number 65-71-4 Molecular Weight 126.113
Density 1.4±0.1 g/cm3 Boiling Point 403.8±37.0 °C at 760 mmHg
Molecular Formula C5H6N2O2 Melting Point 316 °C
MSDS Chinese USA Flash Point 198.0±26.5 °C

 Use of Thymine


Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.

 Names

Name Thymine
Synonym More Synonyms

 Thymine Biological Activity

Description Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 403.8±37.0 °C at 760 mmHg
Melting Point 316 °C
Molecular Formula C5H6N2O2
Molecular Weight 126.113
Flash Point 198.0±26.5 °C
Exact Mass 126.042931
PSA 65.72000
LogP -2.09
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.614
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP2100000
CHEMICAL NAME :
Thymine
CAS REGISTRY NUMBER :
65-71-4
LAST UPDATED :
199707
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C5-H6-N2-O2
MOLECULAR WEIGHT :
126.13
WISWESSER LINE NOTATION :
T6N CNJ BQ DQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
1 gm/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7246 No. of Facilities: 437 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 4219 (estimated) No. of Female Employees: 2161 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XP2100000
HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles106

More Articles
Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.

MAbs 7(2) , 403-12, (2015)

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-exp...
In vitro investigations on the effect of dermal fibroblasts on keratinocyte responses to ultraviolet B radiation.

Photochem. Photobiol. 90(6) , 1332-9, (2014)

Exposure to ultraviolet radiation is closely linked to the development of skin cancers in humans. The ultraviolet B (UVB) radiation wavelength (280-320 nm), in particular, causes DNA damage in epiderm...
An amplified electrochemical strategy using DNA-QDs dendrimer superstructure for the detection of thymine DNA glycosylase activity.

Biosens. Bioelectron. 71 , 249-55, (2015)

A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA label with the electrochemical method...

 Synonyms

5-Methyl-2,4(1H,3H)-pyrimidinedione
Clospirazine
5-methylpyrimidine-2,4-dione
5-Methyluracil
THYMINE extrapure
Thymine
4-Hydroxy-5-methylpyrimidin-2(1H)-one
2,4(1H,3H)-Pyrimidinedione, 5-methyl-
5-Methylpyrimidine-2,4-diol
ThyMine 5GR
5-Methylpyrimidin-2,4(1H,3H)-dion
2,4-dihydroxy-5-methylpyrimidine
D-THYMIDINE
THYMIN
EINECS 200-616-1
5-Methylpyrimidine-2,4(1H,3H)-dione
MFCD00006026
Zidovudine Impurity 3
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  • Product Name: Thymine
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  • Purity: 98.0%
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Thymine suppliers

Price: ￥550/10 mM * 1 mL in DMSO

Reference only. check more Thymine price

Related Compounds: More...
Thymine
28854-96-8
Thymine-d3
68941-98-0
DH-Thymine
146369-86-0
Thymine-13C
200417-68-1
Thymine-d4-1
156054-85-2
vinylthymine
20245-84-5
1-BOC-thymine
402848-98-0
N3-Bz-thymine
4330-20-5
4-Thiothymine
35455-79-9
Chemsrc provides Thymine(CAS#:65-71-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thymine are included as well.>> amp version: Thymine

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