Pilocarpine
Pilocarpine structure
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Common Name | Pilocarpine | ||
|---|---|---|---|---|
| CAS Number | 92-13-7 | Molecular Weight | 208.257 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 431.8±18.0 °C at 760 mmHg | |
| Molecular Formula | C11H16N2O2 | Melting Point | 34℃ | |
| MSDS | N/A | Flash Point | 215.0±21.2 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
J. Neurosci. 34(29) , 9720-35, (2014) The mechanisms of action of many CNS drugs have been studied extensively on the level of their target proteins, but the effects of these compounds on the level of complex CNS networks that are composed of different types of excitatory and inhibitory neurons a... |
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Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Exp. Neurol. 257 , 39-49, (2014) The alterations in GABA release have not yet been systematically measured along the natural course of temporal lobe epilepsy. In this work, we analyzed GABA extracellular concentrations (using in vivo microdialysis under basal and high K(+)-evoked conditions)... |
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Dynamics of hippocampal acetylcholine release during lithium-pilocarpine-induced status epilepticus in rats.
J. Neurochem. 131(1) , 42-52, (2014) The lithium-pilocarpine model is a rat model of epilepsy that mimics status epilepticus in humans. Here, we report changes of acetylcholine (ACh) release in the hippocampus before, during and after status epilepticus as monitored by microdialysis in unanesthe... |
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Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.
J. Clin. Invest. 124(3) , 1255-67, (2014) Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 expression have potential for preventing excitotoxicity, which contributes to neurona... |
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Three-dimensional evaluation of accommodating intraocular lens shift and alignment in vivo.
Ophthalmology 121(1) , 45-55, (2014) To quantify 3-dimensionally the anterior segment geometry, biometry, and lens position and alignment in patients before and after implantation of the Crystalens-AO (Bausch & Lomb, Rochester, NY) accommodating intraocular lens (A-IOL).Prospective, observationa... |
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Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
Toxicology 323 , 19-25, (2014) Poisoning with organophosphates (OPs) may induce status epilepticus (SE), leading to severe brain damage. Our objectives were to investigate whether OP-induced SE leads to the emergence of spontaneous recurrent seizures (SRSs), the hallmark of chronic epileps... |
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Effect of Argemone mexicana (L.) against lithium-pilocarpine induced status epilepticus and oxidative stress in Wistar rats.
Indian J. Exp. Biol. 53(1) , 31-5, (2015) Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by administration of ... |
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Additional antiepileptic mechanisms of levetiracetam in lithium-pilocarpine treated rats.
PLoS ONE 8(10) , e76735, (2013) Several studies have addressed the antiepileptic mechanisms of levetiracetam (LEV); however, its effect on catecholamines and the inflammatory mediators that play a role in epilepsy remain elusive. In the current work, lithium (Li) pretreated animals were adm... |
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Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy.
Einstein (Sao. Paulo.) 10(2) , 247-52, (2012) Magnetic resonance images are useful in the study of experimental models of temporal lobe epilepsy. The manganese-enhanced MRI (MEMRI) technique is of interest since it combines the effects caused by manganese on the increased contrast in activated cell popul... |
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Alpha melanocyte stimulating hormone (-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
Life Sci. 93(20) , 723-31, (2013) Alpha-melanocyte stimulating hormone (-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been... |