Life Sciences 2013-10-01

Alpha melanocyte stimulating hormone (-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.

FernandaRossatto Temp, AlineCarr_ Santos, JoseaneRighes Marafiga, AnaCl_udia Jesse, Qu_liFernandes Lenz, SaraMarquesan Oliveira, GustavoPetri Guerra, TeresaNieves Scimonelli, CarlosFernando Mello

Index: Life Sci. 93(20) , 723-31, (2013)

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Abstract

Alpha-melanocyte stimulating hormone (-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether -MSH modifies seizures. Therefore, in the current study we determined whether -MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures.