Pilocarpine nitrate
Pilocarpine nitrate structure
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Common Name | Pilocarpine nitrate | ||
|---|---|---|---|---|
| CAS Number | 148-72-1 | Molecular Weight | 271.27000 | |
| Density | N/A | Boiling Point | 520.5ºC at 760 mmHg | |
| Molecular Formula | C11H17N3O5 | Melting Point | 173,5-174°C | |
| MSDS | Chinese USA | Flash Point | 268.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
J. Neurosci. 34(29) , 9720-35, (2014) The mechanisms of action of many CNS drugs have been studied extensively on the level of their target proteins, but the effects of these compounds on the level of complex CNS networks that are composed of different types of excitatory and inhibitory neurons a... |
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Development and characterization of pilocarpine loaded Eudragit nanosuspensions for ocular drug delivery.
J. Biomed. Nanotechnol. 9(1) , 124-31, (2013) With aim of improving the availability of drug at intraocular level and to reduce the frequency of drug administration, pilocarpine nitrate nanosuspensions were made from inert polymer resin (Eudragit RL 100) with varying drug to polymer ratios using Lutrol F... |
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Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Exp. Neurol. 257 , 39-49, (2014) The alterations in GABA release have not yet been systematically measured along the natural course of temporal lobe epilepsy. In this work, we analyzed GABA extracellular concentrations (using in vivo microdialysis under basal and high K(+)-evoked conditions)... |
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Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
Nat. Chem. Biol. 4 , 256-63, (2008) Fragile X syndrome is caused by the functional loss of the fragile X mental retardation 1 (FMR1) gene. Deletion of the FMR1 ortholog in Drosophila melanogaster (Fmr1) recapitulates many phenotypes associated with fragile X syndrome. We have discovered that Fm... |
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Evaluation of cytotoxicity of some common ophthalmic drugs.
Eur. Rev. Med. Pharmacol. Sci. 19 , 1945-50, (2015) The study was aimed at evaluating the in vitro cytotoxicity of some commonly used drugs in ophthalmology. Hydrocortisone sodium succinate, Dexamethasone sodium phosphate, 5-Fluorouracil, Tobramycin and Pilocarpine nitrate are frequently used in various indica... |
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Three-dimensional evaluation of accommodating intraocular lens shift and alignment in vivo.
Ophthalmology 121(1) , 45-55, (2014) To quantify 3-dimensionally the anterior segment geometry, biometry, and lens position and alignment in patients before and after implantation of the Crystalens-AO (Bausch & Lomb, Rochester, NY) accommodating intraocular lens (A-IOL).Prospective, observationa... |
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Are morphologic and functional consequences of status epilepticus in infant rats progressive?
Neuroscience 235 , 232-49, (2013) The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen ... |
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Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats.
Epilepsy Behav. 28(3) , 432-6, (2013) Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE... |
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Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Epilepsia 54(4) , 649-57, (2013) Epilepsy is a complex disease characterized by a predisposition toward seizures. There are numerous barriers to the successful treatment of epilepsy. For instance, current antiepileptic drugs have adverse side effects and variable efficacies. Furthermore, the... |