Pentetrazol
Pentetrazol structure
|
Common Name | Pentetrazol | ||
|---|---|---|---|---|
| CAS Number | 54-95-5 | Molecular Weight | 138.17000 | |
| Density | 1.73 g/cm3 (20ºC) | Boiling Point | 194 °C12 mm Hg(lit.) | |
| Molecular Formula | C6H10N4 | Melting Point | 59-61 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 194°C/12mm | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
Effect of curcumin against pentylenetetrazol-induced seizure threshold in mice: possible involvement of adenosine A1 receptors.
Phytother Res. 28(5) , 714-21, (2014) Curcumin, obtained from Curcuma longa, has been in use for manifold human disorders. The present study explores the effect of curcumin against pentylenetetrazol (PTZ) seizure threshold in mice. The possible involvement of adenosine receptor(s) mechanism was a... |
|
|
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery.
Int. J. Pharm. 495 , 816-26, (2015) Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present study was the development of brain... |
|
|
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Brain Res. Bull. 114 , 70-8, (2015) The N-methyl-d-aspartate (NMDA) receptor plays an important role in the pathophysiology of several neurological diseases, including epilepsy. The present study investigated the effect of NMDA receptor NR2B subunits on pentylenetetrazole (PTZ)-kindling-induced... |
|
|
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
J. Neurosci. 35 , 9741-53, (2015) Persistent firing of entorhinal cortex (EC) pyramidal neurons is a key component of working and spatial memory. We report here that a pro-brain-derived neurotrophic factor (proBDNF)-dependent p75NTR signaling pathway plays a major role in excitability and per... |
|
|
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
J. Psychopharmacol. 28(10) , 923-34, (2014) Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well as the neural mechanisms involved. Animal models such as barbiturate sleep-induction, light-dark box, elevated plus maze, forced swimming test, tail suspension... |
|
|
High dosage of cannabidiol (CBD) alleviates pentylenetetrazole-induced epilepsy in rats by exerting an anticonvulsive effect.
Int. J. Clin. Exp. Med. 8 , 8820-7, (2015) The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy. The chronic epilepsy rat model was prepared by intraperitoneally injecting pentylenetetrazole to the rats pre-treated with CBD (10, ... |
|
|
JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.
ACS Chem. Neurosci. 5(10) , 1005-19, (2014) Adenosine A2A antagonists are believed to have therapeutic potential in the treatment of Parkinson's disease (PD). We have characterized the dual adenosine A2A/A1 receptor antagonist JNJ-40255293 (2-amino-8-[2-(4-morpholinyl)ethoxy]-4-phenyl-5H-indeno[1,2-d]p... |
|
|
Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency.
J. Pharmacol. Exp. Ther. 352(1) , 43-52, (2015) The medium chain triglyceride (MCT) ketogenic diet is a major treatment of drug-resistant epilepsy but is problematic, particularly in adults, because of poor tolerability. Branched derivatives of octanoic acid (OA), a medium chain fat provided in the diet ha... |
|
|
Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats.
Indian J. Exp. Biol. 53 , 446-51, (2015) Panchagavya Ghrita (PG), according to Ayurvedic formulary of India (AFI), is used to treat epilepsy (apasmara), fever (jvara), mania (unmade) and jaundice (kamala). In the present study, we examined its effect on convulsions, oxidative stress and cognitive im... |