Chrysophanic acid
Chrysophanic acid structure
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Common Name | Chrysophanic acid | ||
|---|---|---|---|---|
| CAS Number | 481-74-3 | Molecular Weight | 254.238 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 489.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O4 | Melting Point | 194-198 °C | |
| MSDS | Chinese USA | Flash Point | 263.9±25.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microglia.
Int. J. Clin. Exp. Med. 8 , 3447-55, (2015) In this study, chrysophanol, isolated from a marine fungus, was examined for its protective effects against inflammatory responses and oxidative stress in BV2 microglia. Chrysophanol was studied to assess its capabilities of protecting against lipopolysacchar... |
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Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.
Chin. J. Integr. Med. 18(9) , 708-13, (2012) To investigate the effect of prescription compatibility on the pharmacokinetics of components from Dachengqi Decoction (DCQD, ) in rats.Twenty-four male rats were randomly and equally divided into the DCQD group, Dahuang (Radix et Rhizoma Rhei, Polygonaceae) ... |
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Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015) Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two or more herbs based on the clinical settings and the proper... |
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Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats.
Chem. Res. Toxicol. 28 , 1120-32, (2015) Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. Therefore, the present study was designed to identify the key ... |
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The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells.
DNA Cell. Biol. 34(3) , 178-88, (2015) The traditional Chinese medicinal formula BDL301 has been used to inhibit inflammation for hundreds of years. The development of colorectal cancer and chronic inflammation are closely related. In this study, we investigated whether BDL301 could inhibit tumor ... |
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The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats.
Eur. J. Drug Metab. Pharmacokinet. 40 , 379-88, (2015) In the study, it was hypothesized that Rhubarb Anthraquinones synergistically enhanced the purgative effect on constipation rat from the direct and indirect pathway at the same time. A validated HPLC method was successfully applied to elucidate the synergism ... |
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Anti-metastatic effects of Rheum Palmatum L. extract in human MDA-MB-231 breast cancer cells.
Environ. Toxicol. Pharmacol. 40 , 30-8, (2015) Rheum palmatum L. (RP) has been widely used in traditional medicine for the treatment of various diseases in Asian countries. The molecular mechanism of its anti-metastasis effect remains elusive. The present study assessed the effect of RP ethanol extract (R... |
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Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011) The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components found in TCMs were identified as putative QSIs based on molecu... |
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HPLC and HPTLC methods by design for quantitative characterization and in vitro anti-oxidant activity of polyherbal formulation containing Rheum emodi.
J. Chromatogr. Sci. 52(8) , 911-8, (2014) Safoof-e-Pathar phori (SPP) is a traditional polyherbal formulation and has been used since long time for its anti-urolithiatic activity. It contains three plant constituents Didymocarpous pedicellata, Dolichous biflorus and Rheum emodi. Emodin and chrysophan... |
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Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.
J. Chromatogr. A. 1218(42) , 7655-62, (2011) A method for simultaneous determination of eight adulterants including two appetite suppressants, two energy expenditure-enhancing drugs, one diuretic and three cathartics in slimming functional foods by high performance liquid chromatography with electrospra... |