Carboxypeptidase B
Carboxypeptidase B structure
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Common Name | Carboxypeptidase B | ||
|---|---|---|---|---|
| CAS Number | 9025-24-5 | Molecular Weight | 610.721 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 966.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C31H38N4O7S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 538.4±34.3 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B.
Biotechnol. Prog. 25(4) , 1064-70, (2009) Insulin is a polypeptide hormone which is produced by the beta-cell of pancreas and controls the blood glucose level in the human body. Enzymatic modification of human proinsulin using trypsin and carboxypeptidase B generally causes high accumulation of insul... |
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Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: First insights from steered molecular dynamics simulations
J. Mol. Graph. Model. 38 , 298-303, (2012) Graphical abstract |
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Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.
J. Med. Chem. 56(19) , 7527-35, (2013) Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) is a zinc-containing carboxypeptidase and significantly inhibits fibrinolysis. TAFIa inhibitors are thus expected to act as profibrinolytic agents. We recently reported the design and synthesis of ... |
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Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
Life Sci. 31(16-17) , 1793-6, (1982)
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Analysis of a new crystal form of procarboxypeptidase B: further insights into the catalytic mechanism.
Biopolymers 93(2) , 178-85, (2010) A new triclinic crystal structure form of porcine pancreatic procarboxypeptidase B (PCPB) was obtained at higher resolution than the previously known tetragonal crystal structure. This new crystal polymorph has allowed for a corrected, accurate assignment of ... |
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Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
Clin. Chim. Acta 97(1) , 39-43, (1979) Enzyme activity against hippuryl-L-arginine was studied in cultured skin fibroblasts from controls and cystic fibrosis patients. The enzyme had a lysosomal distribution and an acid optimum of pH 4.5 with little or no activity present above pH 7.0. Dithiothrei... |
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Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen.
J. Immunol. 192(2) , 658-65, (2014) Dendritic cells (DCs) are important orchestrators of the immune response, ensuring that immunity against pathogens is generated, whereas immunity against healthy tissues is prevented. Using the tumor Ag MUC1, we previously showed that i.v. immunization of MUC... |
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Increasing the refolding efficiency in vitro by site-directed mutagenesis of Cys383 in rat procarboxypeptidase B
Enzyme Microb. Technol. 49(2) , 139-45, (2011) This study examines a novel method to reduce the probability of disulfide mismatches during the refolding process by the replacement of cysteines within a protein. Specifically, Cys383 of recombinant rat procarboxypeptidase B was replaced by other amino acids... |
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Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy.
Pancreas 39(2) , 171-4, (2010) There is a need to develop methods of early diagnosis for pancreatic cancer. Pancreatic juice is easily collected by endoscopic retrograde cholangiopancreatography and may facilitate diagnosis using molecular markers. The aim of this work was to explore the f... |
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Studies on the expression and processing of human proinsulin derivatives encoded by different DNA constructs.
Biochim. Biophys. Acta 1834(10) , 2116-23, (2013) A synthetic gene encoding human proinsulin, containing Escherichia coli preferred codons, with an additional N-terminal methionine, was used for the expression, of M-proinsulin and construction of nine derivatives. No improvement in expression was noted, rela... |