Carboxypeptidase B

Modify Date: 2024-01-02 12:28:32

Carboxypeptidase B structure	Common Name	Carboxypeptidase B
	CAS Number	9025-24-5	Molecular Weight	610.721
	Density	1.3±0.1 g/cm3	Boiling Point	966.7±65.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₃₈N₄O₇S	Melting Point	N/A
	MSDS	USA	Flash Point	538.4±34.3 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Carboxypeptidase B

Carboxypeptidase B is a peptide exonuclease that can specifically degrade peptide chains. Carboxypeptidase B is progressively degraded from the C-terminal to release free amino acids. Carboxypeptidase B hydrolyzes only peptide bonds with basic amino acids (such as arginine and lysine) as C-terminal residues[1][2].

Name	4-[[1-[[1-[2-[(1-benzylsulfanyl-1-oxo-3-phenylpropan-2-yl)carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Synonym	More Synonyms

Description	Carboxypeptidase B is a peptide exonuclease that can specifically degrade peptide chains. Carboxypeptidase B is progressively degraded from the C-terminal to release free amino acids. Carboxypeptidase B hydrolyzes only peptide bonds with basic amino acids (such as arginine and lysine) as C-terminal residues[1][2].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. FOLK JE, et al. The kinetics of carboxypeptidase B activity. II. Kinetic parameters of the cobalt and cadmium enzymes. J Biol Chem. 1962 Oct;237:3100-4. [2]. Qian X, et al. Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunol. 2019 Nov;94:434-446.

Description

Related Catalog

Research Areas >> Metabolic Disease

References

[1]. FOLK JE, et al. The kinetics of carboxypeptidase B activity. II. Kinetic parameters of the cobalt and cadmium enzymes. J Biol Chem. 1962 Oct;237:3100-4.

[2]. Qian X, et al. Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunol. 2019 Nov;94:434-446.

Density	1.3±0.1 g/cm3
Boiling Point	966.7±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₃₈N₄O₇S
Molecular Weight	610.721
Flash Point	538.4±34.3 °C
Exact Mass	610.246094
PSA	197.75000
LogP	3.26
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.595
Storage condition	−20°C

Carboxypeptidase B MSDS(Chinese)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H334-H335
Precautionary Statements	P261-P305 + P351 + P338-P342 + P311
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3

Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B.

Biotechnol. Prog. 25(4) , 1064-70, (2009)

Insulin is a polypeptide hormone which is produced by the beta-cell of pancreas and controls the blood glucose level in the human body. Enzymatic modification of human proinsulin using trypsin and car...

Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: First insights from steered molecular dynamics simulations

J. Mol. Graph. Model. 38 , 298-303, (2012)

Graphical abstract

Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.

J. Med. Chem. 56(19) , 7527-35, (2013)

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) is a zinc-containing carboxypeptidase and significantly inhibits fibrinolysis. TAFIa inhibitors are thus expected to act as profibrinolyti...

Protaminase

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Peptidyl-L-lysine(L-arginine) hydrolase

Carboxypeptidase B from human pancreas

Protaminase,AEBSF treated

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Carboxypeptidase B from porcine pancreas