amphetamine
amphetamine structure
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Common Name | amphetamine | ||
|---|---|---|---|---|
| CAS Number | 300-62-9 | Molecular Weight | 135.20600 | |
| Density | 0.947g/cm3 | Boiling Point | 201.499ºC at 760 mmHg | |
| Molecular Formula | C9H13N | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 9℃ | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Evaluation of13C- and2H-labeled internal standards for the determination of amphetamines in biological samples, by reversed-phase ultra-high performance liquid chromatography–tandem mass spectrometry
J. Chromatogr. A. 1344 , 83-90, (2014) • Several new 13C labeled internal standards (ISs) used for the first time as ISs. • 13C labeled ISs better suited than 2H labeled ISs in RP LC–MS/MS analysis. • 13C labeled ISs behave as their analytes in chromatographic separations. • ISs with few 2H are be... |
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Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.
Neuron 81(1) , 77-90, (2014) Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as ... |
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Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence.
J. Neurosci. 34(29) , 9484-96, (2014) The mesofrontal dopaminergic circuit, which connects the midbrain motivation center to the cortical executive center, is engaged in control of motivated behaviors. In addition, deficiencies in this circuit are associated with adolescent-onset psychiatric diso... |
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Cholinergic control over attention in rats prone to attribute incentive salience to reward cues.
J. Neurosci. 33(19) , 8321-35, (2013) Some rats [sign-trackers (STs)] are especially prone to attribute incentive salience to reward cues, relative to others [goal-trackers (GTs)]. Thus, reward cues are more likely to promote maladaptive reward-seeking behavior in STs than GTs. Here, we asked whe... |
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In-sample derivatization-solid-phase microextraction of amphetamines and ecstasy related stimulants from water and urine.
Anal. Chim. Acta 770 , 75-84, (2013) A solid-phase microextraction (SPME) method for the determination of five amphetamine type stimulants (ATSs) in water and urine samples is presented. Analytes were simultaneously derivatized with iso-butyl chloroformate (iBCF) in the aqueous sample while bein... |
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Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.
J. Neurosci. 33(25) , 10405-26, (2013) Locomotion and cue-dependent behaviors are modified through corticostriatal signaling whereby short-term increases in dopamine availability can provoke persistent changes in glutamate release that contribute to neuropsychiatric disorders, including Parkinson'... |
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Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: possible contribution of large-conductance calcium-activated potassium channels.
Toxicol. Lett. 223(2) , 139-45, (2013) Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice variant expression of large conductance Ca(2+)-activated K(+) (... |
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PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.
Nat. Chem. Biol. 10(7) , 582-9, (2014) Phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates the function of ion channels and transporters. Here, we demonstrate that PIP2 directly binds the human dopamine (DA) transporter (hDAT), a key regulator of DA homeostasis and a target of the psychostimu... |
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Biphasic mechanisms of amphetamine action at the dopamine terminal.
J. Neurosci. 34(16) , 5575-82, (2014) In light of recent studies suggesting that amphetamine (AMPH) increases electrically evoked dopamine release ([DA]o), we examined discrepancies between these findings and literature that has demonstrated AMPH-induced decreases in [DA]o. The current study has ... |
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Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia.
JAMA Psychiatry 71(12) , 1364-72, (2014) An increased risk for psychosis is observed in people with hearing impairment. According to the social defeat hypothesis, the long-term experience of exclusion leads to enhanced baseline activity and/or sensitization of the dopamine system and puts the indivi... |