Selenium(IV) chloride (-8 mesh)

Selenium(IV) chloride (-8 mesh) Structure
Selenium(IV) chloride (-8 mesh) structure
Common Name Selenium(IV) chloride (-8 mesh)
CAS Number 10026-03-6 Molecular Weight 220.77200
Density 2.6 g/mL at 25 °C(lit.) Boiling Point 288ºC
Molecular Formula Cl4Se Melting Point 200-210ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.

Proc. Natl. Acad. Sci. U. S. A. 103(47) , 17949-54, (2006)

Prostaglandin (PG) D2 has been proposed to be essential for the initiation and maintenance of the physiological sleep of rats because intracerebroventricular administration of selenium tetrachloride (SeCl4), a selective inhibitor of PGD synthase (PGDS), was s...

Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero.

J. Neurosci. 22(13) , 5679-86, (2002)

It has been proposed that prostaglandin (PG) D(2) induces physiological sleep in mammals by acting on sleep centers located in the anterior hypothalamus. In fetal sheep, definitive rapid-eye-movement and non-rapid-eye-movement sleep states appear at approxima...

Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase.

Proc. Natl. Acad. Sci. U. S. A. 88(20) , 9046-50, (1991)

Prostaglandin (PG) D2 has been postulated to be an endogenous sleep-promoting factor in rats, and SeCl4 and Na2SeO3 recently have been shown to inhibit the PGD synthase (prostaglandin-H2 D-isomerase, EC 5.3.99.2) activity of rat brain. The effect of these sel...

Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds.

Arch. Biochem. Biophys. 289(1) , 161-6, (1991)

Various inorganic selenocompounds dose-dependently inhibited the rat brain prostaglandin (PG) D synthase, both in the purified enzyme preparation and in the crude brain supernatant. All of the quadrivalent selenium compounds tested had a very limited range of...

Retrograde tracing of zinc-containing neurons by selenide ions: a survey of seven selenium compounds.

J. Histochem. Cytochem. 40(4) , 575-9, (1992)

The autometallographic retrograde tracing of zinc-containing neurons by intracerebral injection of sodium selenite (Na2SeO3), introduced by Danscher in 1982, has recently been described in more detail. Intracerebral injections of both sodium selenide (Na2Se) ...

Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats.

Brain Res. 623(1) , 65-71, (1993)

Prostaglandin (PG) D2 has been postulated to be an endogenous sleep-promoting factor. Biosynthesis of PGD2 is catalyzed by PGD synthase (prostaglandin-H2 D-isomerase, EC 5.3.99.2), the activity of which is inhibited by inorganic selenium compounds such as SeC...

5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors.

Org. Biomol. Chem. 8(4) , 828-34, (2010)

Low molecular weight seleno-organic compounds exhibit glutathione peroxidase (GPx)-like activity; the well-known compound ebselen is being used in clinical trials as a stroke medication. Here, we describe the facile one-step synthesis of novel 5-selenized sal...