(-)-codeine
(-)-codeine structure
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Common Name | (-)-codeine | ||
|---|---|---|---|---|
| CAS Number | 76-57-3 | Molecular Weight | 299.364 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 462.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H21NO3 | Melting Point | 154 - 156ºC | |
| MSDS | N/A | Flash Point | 233.2±28.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study.
Life Sci. 122 , 42-50, (2015) Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced to... |
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Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection.
Talanta 130 , 221-5, (2014) Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine applicat... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.
SAAD Dig. 29 , 70-81, (2013)
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Inhibition screening method of microsomal UGTs using the cocktail approach.
Eur. J. Pharm. Sci. 71 , 35-45, (2015) A rapid method for the simultaneous determination of the in vitro activity of the 10 major human liver UDP-glucuronosyltransferase (UGT) enzymes was developed based on the cocktail approach. Specific substrates were first selected for each UGT: etoposide for ... |
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High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction.
J. Chromatogr. A. 1374 , 40-9, (2014) Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are methods that can, without sacrificing time, easily remove matri... |
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Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology.
J. Anal. Toxicol. 38(8) , 495-506, (2014) High-resolution mass spectrometry (HRMS) is being applied in postmortem drug screening as an alternative to nominal mass spectrometry, and additional evaluation in quantitative casework is needed. We report quantitative analysis of benzoylecgonine, citalopram... |
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Discovery of syn-/anti-cocaine-N-oxide diastereomers in unwashed postmortem hair via LC-MS-MS.
J. Anal. Toxicol. 38(6) , 360-7, (2014) The discovery of two cocaine-N-oxide (CNO) diastereomers, syn- and anti-CNO, is reported for the first time. Prior to this study, only one structural form of CNO was known to exist and has not been analyzed in hair before. CNO is a metabolite of cocaine (COC)... |
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Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters.
Acta. Pharm. 64(2) , 223-32, (2014) There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB). The aim of this study was to investigate the effect of natural and synthetic substances on the e... |
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
J. Med. Chem. 51 , 5932-42, (2008) The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered ora... |