STF 31
STF 31 structure
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Common Name | STF 31 | ||
|---|---|---|---|---|
| CAS Number | 724741-75-7 | Molecular Weight | 423.528 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H25N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression.
Biochim. Biophys. Acta 1847 , 1254-66, (2015) Abnormal accumulation of oncometabolite fumarate and succinate is associated with inhibition of mitochondrial function and carcinogenesis. By competing with α-ketoglutarate, oncometabolites also activate hypoxia inducible factors (HIFs), which makes oncometab... |
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NAMPT is the cellular target of STF-31-like small-molecule probes.
ACS Chem. Biol. 9(10) , 2247-54, (2014) The small-molecule probes STF-31 and its analogue compound 146 were discovered while searching for compounds that kill VHL-deficient renal cell carcinoma cell lines selectively and have been reported to act via direct inhibition of the glucose transporter GLU... |
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Glucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells.
Sci. Rep. 6 , 21629, (2016) The mesenchymal state in cancer is usually associated with poor prognosis due to the metastatic predisposition and the hyper-activated metabolism. Exploiting cell glucose metabolism we propose a new method to detect mesenchymal-like cancer cells. We demonstra... |