Tert-Butyl isocyanide
Tert-Butyl isocyanide structure
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Common Name | Tert-Butyl isocyanide | ||
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| CAS Number | 7188-38-7 | Molecular Weight | 83.132 | |
| Density | 0.735 g/mL at 25 °C(lit.) | Boiling Point | 91 °C(lit.) | |
| Molecular Formula | C5H9N | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | -2 °C | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Optimization of the Ugi reaction using parallel synthesis and automated liquid handling.
J. Vis. Exp. (21) , doi:10.3791/942, (2008) The optimization of a Ugi reaction involving the mixing of furfurylamine, benzaldehyde, boc-glycine and t-butylisocyanide is described. Triplicate runs of 48 parallel experiments are reported, varying concentration, solvent and the excess of some of the reage... |
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Palladium-catalyzed synthesis of isocoumarins and phthalides via tert-butyl isocyanide insertion.
J. Org. Chem. 77(22) , 10321-8, (2012) A novel and highly efficient strategy for the synthesis of isocoumarins and phthalides through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. This process, providing one of the simplest methods for the synthesis of t... |
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Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile.
Org. Biomol. Chem. 8(16) , 3631-4, (2010) With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product, tert-butyl isocyanide as a useful convertible isonitrile has been explored for the first time affording ac... |
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Strong carbon-surface dative bond formation by tert-butyl isocyanide on the Ge(100)-2 × 1 surface.
J. Am. Chem. Soc. 136(16) , 5848-51, (2014) Carbon dative bond formation between an organic molecule and a semiconductor surface is reported here for the first time. Our studies show that the adsorption of tert-butyl isocyanide on the (100) surface of germanium, measured using Fourier transform infrare... |
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Structural and spectroscopic studies of some copper(I) halide tert-butyl isocyanide adducts.
Dalton Trans. (13) , 1710-20, (2008) Single-crystal structural characterizations confirm the existence of the unusual 1 : 4 copper(I) halide : unidentate ligand adducts [Cu(CNt-Bu)4]X for X = Cl, Br (two forms), I (the chloride and one form of the bromide being solvated) with crystal packing dom... |
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Synthesis and dynamic NMR study of ketenimines derived from tert-butyl isocyanide, alkyl 2-arylamino-2-oxo-acetates, and dialkyl acetylenedicarboxylates.
Mol. Divers. 8(4) , 431-5, (2004) The adduct produced in the reaction between tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped by alkyl 2-arylamino-2-oxo-acetates. When the aryl group is 2-methyl-6-nitrophenyl or 2,6-di-isopropylphenyl, the product exists as two stable ro... |
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Variable pi-bonding in iron(II) porphyrinates with nitrite, CO, and tert-butyl isocyanide: characterization of [Fe(TpivPP)(NO2)(CO)]-.
Inorg. Chem. 43(9) , 2932-42, (2004) The addition of the strongly pi-bonding ligands CO or tert-butyl isocyanide to the low-spin five-coordinate iron(II) nitrite species [Fe(TpivPP)(NO2)]- (TpivPP = picket fence porphyrin) gives two new six-coordinate species [Fe(TpivPP)(NO2)(CO)]- and [Fe(TpivP... |
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Palladium-catalyzed formylation of aryl halides with tert-butyl isocyanide.
Org. Lett. 16(13) , 3492-5, (2014) A novel palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH has been demonstrated, which provides a strategy toward important aldehydes with moderate to excellent yield. The advantage of this reaction includes milder cond... |
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Evidence for a slow tertiary relaxation in the reaction of tert-butyl isocyanide with horseradish peroxidase.
Biochemistry 35(5) , 1500-5, (1996) The kinetics of tert-butyl isocyanide binding to the heme protein horseradish peroxidase (HRP) at 22 degrees C was examined on all time scales, from minutes to picoseconds, in aqueous borate buffer at pH 9.08. Unlike myoglobin (Mb) or hemoglobin, HRP shows tw... |
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Organometallics 12 , 2414, (1993)
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