5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE

5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE Structure
5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE structure
Common Name 5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE
CAS Number 3493-13-8 Molecular Weight 526.35000
Density N/A Boiling Point N/A
Molecular Formula C15H23IN6O5S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist.

J. Pharm. Biomed. Anal. 94 , 36-44, (2014)

Structural modification of the GluN2B selective NMDA receptor antagonist ifenprodil led to the 3-benzazepine WMS-1410 with similar GluN2B affinity but higher receptor selectivity. Herein the in vitro and in vivo biotransformation of WMS-1410 is reported. Incu...

Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.

J. Biol. Chem. 287 , 1426-1434, (2012)

In the malarial parasite Plasmodium falciparum, a multifunctional phosphoethanolamine methyltransferase (PfPMT) catalyzes the methylation of phosphoethanolamine (pEA) to phosphocholine for membrane biogenesis. This pathway is also found in plant and nematodes...

DNA methyltransferases: mechanistic models derived from kinetic analysis.

Crit. Rev. Biochem. Mol. Biol. 47(2) , 97-193, (2012)

The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form of epigenetic modification. It is virtually ubiquitous, ex...

Radical AdoMet enzymes in complex metal cluster biosynthesis.

Biochim. Biophys. Acta 1824(11) , 1254-63, (2012)

Radical S-adenosylmethionine (AdoMet) enzymes comprise a large superfamily of proteins that engage in a diverse series of biochemical transformations through generation of the highly reactive 5'-deoxyadenosyl radical intermediate. Recent advances into the bio...

Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.

J. Am. Chem. Soc. 133 , 17134-17137, (2011)

Human catechol-O-methyltransferase (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine. Site-specific mutants at three positions (Tyr68, Trp38, and Val108) have been characterized with regard to product distribution, catalytic ef...

SAMe and HuR in liver physiology: usefulness of stem cells in hepatic differentiation research.

Methods Mol. Biol. 826 , 133-149, (2012)

S-Adenosylmethionine, abbreviated as SAM, SAMe or AdoMet, is the principal methyl group donor in the mammalian cell and the first step metabolite of the methionine cycle, being synthesized by MAT (methionine adenosyltransferase) from methionine and ATP. About...

DNA methyltransferase assays.

Methods Mol. Biol. 791 , 157-177, (2011)

DNA methyltransferases are important enzymes and their inhibition has many potential applications. The investigation of DNA methyltransferases as well as screening for potential inhibitors requires specialized enzyme assays. In this chapter, we describe three...