1-nitrosoazepane
1-nitrosoazepane structure
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Common Name | 1-nitrosoazepane | ||
|---|---|---|---|---|
| CAS Number | 932-83-2 | Molecular Weight | 128.17200 | |
| Density | 1.13g/cm3 | Boiling Point | 247ºC at 760mmHg | |
| Molecular Formula | C6H12N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 103.2ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Strain and sex differences in N-nitrosohexamethyleneimine carcinogenesis in NZB, NZC, NZO, and NZY mice.
J. Natl. Cancer Inst. 73(5) , 1215-8, (1984) The carcinogenic activity of N-nitrosohexamethyleneimine [(NHEX) CAS: 932-83-2; hexahydro-1-nitroso-1H-azepine] was studied in male and female mice of the four inbred strains NZB/BlGd, NZC/BlGd, NZO/BlGd, and NZY/BlGd. A total of 158 mice received NHEX treatm... |
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Carcinogenic effect of nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine in Fischer rats.
Cancer Lett. 12(1-2) , 99-103, (1981) Three homologous cyclic nitrosamines, nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine, were administered to groups of 20 female F344 rats in drinking water, as 0.9 mM solutions. Treatment with the latter 2 compounds lasted 28 weeks, at whi... |
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Carcinogenesis by N-nitrosohexamethyleneimine in NZO inbred mice.
Toxicology 33(3-4) , 251-9, (1984) The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-wee... |
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In vitro formation and properties of beta- and gamma-hydroxy-N-nitrosohexamethyleneimine.
Carcinogenesis 1(12) , 1017-25, (1980) Stable hydroxylated metabolites of N-nitrosohexamethyleneimine (NO-HEX) account for about one-third of the metabolites produced in in vitro reactions using uninduced rat liver microsomes post-microsomal supernatant. The ratio of gamma- to beta-hydroxyNO-HEX t... |
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Comparison of the in vitro metabolism of N-nitrosohexamethyleneimine by rat liver and lung microsomal fractions.
Cancer Res. 42(1) , 59-64, (1982) The in vitro metabolism of N-nitrosohexamethyleneimine by lung and liver microsomes and cytosol from uninduced male Fischer rats is described. Metabolites produced by both organs appeared to be identical. The liver subcellular fractions had a lower Km (0.6 mM... |
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Metabolism and mutagenicity of N-nitrosohexamethyleneimine and its hydroxylated derivatives.
Teratog. Carcinog. Mutagen. 3(1) , 9-17, (1983) There is a direct relationship between the metabolism and mutagenicity of N-nitrosohexamethyleneimine (NO-HEX) in the presence of uninduced and AC- and PB-induced S8 and S9 fractions from rats and hamsters. Although alpha-hydroxylation is the most important p... |
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An unusual ring contraction in the formation of N-nitrosohexamethyleneimine and N-nitrosopiperidine from tolazamide.
Jpn. J. Cancer Res. 81(4) , 324-6, (1990) The previously reported reaction of tolazamide with nitrite, under physiological conditions, to form N-nitrosohexamethyleneimine and surprisingly, N-nitrosopiperidine was confirmed. By using the six-membered ring analogue of tolazamide, 1-(piperidyl)-3-(p-tol... |
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Urinary metabolites of some alicyclic nitrosamines.
IARC Sci. Publ. (57) , 459-63, (1984) We have studied the urinary metabolites of N-nitrosopiperidine, 3- and 4-hydroxy-N-nitrosopiperidine, N-nitroso-4-piperidone, N-nitrosohexamethyleneimine and N-nitroso-heptamethyleneimine. The N-nitrosopiperidines induce primarily oesophageal tumours in rats;... |
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Formation of an N-nitrosamine by oxidation.
Cancer Lett. 32(2) , 187-91, (1986) Tolazamide, an antidiabetic drug, was found to produce N-nitrosohexamethyleneimine (NHM) upon exposure to an oxidizing agent and in the absence of a nitrosating agent. The oxidizing agents were either hydrogen peroxide or oxygen. |
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In vivo binding of N-nitrosopyrrolidine and N-nitrosohexamethyleneimine to non-purine sites on rat liver DNA.
Cancer Lett. 15(3) , 329-34, (1982) Liver DNA and RNA were isolated from rats treated with the liver carcinogens N-nitrosopyrrolidine (NPYR) and N-nitrosohexamethyleneimine (NHX). After hydrolysis in 70% perchloric acid (100 degrees C, 1.0 h), 70% of the radioactivity in both the DNA and RNA hy... |