Cancer Letters 1986-08-01

Formation of an N-nitrosamine by oxidation.

G W Harrington, J Eshraghi, H M Pylypiw, R Kozeniauskas, J P Gillespie

Index: Cancer Lett. 32(2) , 187-91, (1986)

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Abstract

Tolazamide, an antidiabetic drug, was found to produce N-nitrosohexamethyleneimine (NHM) upon exposure to an oxidizing agent and in the absence of a nitrosating agent. The oxidizing agents were either hydrogen peroxide or oxygen.