(+/-)-METHADONE

(+/-)-METHADONE Structure
(+/-)-METHADONE structure
Common Name (+/-)-METHADONE
CAS Number 76-99-3 Molecular Weight 312.46400
Density 1.01 g/cm3 Boiling Point 423.655ºC at 760 mmHg
Molecular Formula C21H24D3NO Melting Point N/A
MSDS N/A Flash Point 48.2 °F
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics.

Anesthesiology 121(6) , 1281-91, (2014)

Interindividual variability and drug interaction studies suggest that blood-brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprot...

Disaccharides in urine samples as markers of intravenous abuse of methadone and buprenorphine.

J. Anal. Toxicol. 37(9) , 652-8, (2013)

Methadone and buprenorphine are commonly used as oral substitutes in opiate maintenance programs to treat persons who are dependent on heroin. During these programs, patients are not allowed to continue using illicit drugs. Abstinence can easily be monitored ...

[Treatment of chronic hepatitis C in drug users: ethic, successful and useful].

Presse Med. 43(12 Pt 1) , 1314-6, (2014)

Risk reduction with buprenorphine-naloxone and methadone: patient's choice.

J. Acquir. Immune Defic. Syndr. 67(5) , e142, (2014)

Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves.

Br. J. Anaesth. 114(1) , 110-20, (2015)

Opioids enhance and prolong analgesia when applied as adjuvants to local anaesthetics (LAs). A possible molecular mechanism for this property is a direct inhibition of voltage-gated Na(+) channels which was reported for some opioids. Methadone is an effective...

Opioid substitution treatment in New Zealand: a 40 year perspective.

N. Z. Med. J. 127(1397) , 57-66, (2014)

We provide an overview of the history and philosophy of the treatment for opioid dependence, which has been dominated by methadone substitution treatment for the past 40 years in New Zealand. Although changes in approach have occurred over this time, influenc...

What is your gut feeling about opioid rotation?

J. Clin. Oncol. 33(3) , e11-2, (2015)

Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT).

CNS Spectr. 19(6) , 509-18, (2014)

To evaluate the impaired attention selection (Stroop interference effect) and general performance [reaction times (RTs)] on the Stroop task among methadone maintenance treatment (MMT) patients with obsessive compulsive disorder (OCD), pathological gambling (P...

Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain.

J. Opioid Manag. 9(5) , 325-33, (2013)

This manuscript evaluates physician monitoring practices and incidence of cardiac side effects following initiation of methadone for treatment of chronic pain as compared to patients who began treatment for chronic pain with morphine sustained release (SR).

HIV prevalence and related risk behaviours among female sex workers in Iran: results of the national biobehavioural survey, 2010.

Sex. Transm. Infect. 89 Suppl 3 , iii37-40, (2013)

To determine the prevalence of HIV and related behavioural risks among Iranian female sex workers (FSW) via the first national biobehavioural surveillance survey.In 2010, 1005 FSW were approached and 872 recruited using facility-based sampling from 21 sites i...