6-Mercaptopurine monohydrate
6-Mercaptopurine monohydrate structure
|
Common Name | 6-Mercaptopurine monohydrate | ||
|---|---|---|---|---|
| CAS Number | 6112-76-1 | Molecular Weight | 170.192 | |
| Density | N/A | Boiling Point | 490.6ºC at 760 mmHg | |
| Molecular Formula | C5H6N4OS | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 250.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Primary sclerosing cholangitis, Crohn's disease and HLA-B27 in black South African women.
Acta Gastroenterol. Belg. 75(4) , 454-7, (2012) Crohn's disease is rare in South African black people and primary sclerosing cholangitis (PSC) is also rare in black patients with IBD, from South Africa. The presence of HLA-B27 is generally associated with seronegative spondylo-arthropathies and correlates ... |
|
|
In-vitro immunosuppression of canine T-lymphocyte-specific proliferation with dexamethasone, cyclosporine, and the active metabolites of azathioprine and leflunomide in a flow-cytometric assay.
Can. J. Vet. Res. 78(3) , 168-75, (2014) A high rate of mortality, expense, and complications of immunosuppressive therapy in dogs underscores the need for optimization of drug dosing. The purpose of this study was to determine, using a flow-cytometric assay, the 50% T-cell inhibitory concentration ... |
|
|
[Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].
Sud. Med. Ekspert. 55(6) , 38-41, (2012) The results of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions with organic solvents of different chemical nature and their mixtures are presented. Synergism between the distribution coefficients was demonstrated during the extra... |
|
|
Methotrexate for induction of remission in ulcerative colitis.
Cochrane Database Syst. Rev. 8 , CD006618, (2014) Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Methot... |
|
|
Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease.
Cochrane Database Syst. Rev. 8 , CD010233, (2014) Crohn's disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions. Purine analogues have been used to maintain surgically-induced remission in CD, but the eff... |
|
|
Telehealth behavioral treatment for medication nonadherence: a pilot and feasibility study.
Eur. J. Gastroenterol. Hepatol. 25(4) , 469-73, (2013) To evaluate an individually tailored multicomponent nonadherence treatment protocol using a telehealth delivery approach in adolescents with inflammatory bowel disease.Nine participants, age 13.71±1.35 years, completed a brief treatment online through Skype. ... |
|
|
Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications.
Gastroenterology 146(1) , 76-84, (2014) Concerns persist about the risk of major congenital anomalies in children of women with inflammatory bowel disease (IBD), and whether medication use affects risk. We assessed these risks, and variations in use of medications by women with IBD before, during, ... |
|
|
Monitoring of thiopurine metabolites - a high-performance liquid chromatography method for clinical use.
J. Pharm. Biomed. Anal. 75 , 145-52, (2013) A high-performance liquid chromatography method capable of measuring thiopurine mono-, di-, and triphosphates separately in red blood cells (RBCs) was developed. RBCs were isolated from whole blood using centrifugation. Proteins were precipitated using dichlo... |
|
|
Augmented Berlin-Frankfurt-Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL).
Cancer 120(23) , 3660-8, (2014) Various trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric-based regimens. Those reports prompted the current investigation of the pediatric augmented Be... |
|
|
Advanced stage anaplastic large cell lymphoma in children and adolescents: results of ANHL0131, a randomized phase III trial of APO versus a modified regimen with vinblastine: a report from the children's oncology group.
Pediatr. Blood Cancer 61(12) , 2236-42, (2014) Optimal therapy for children and adolescents with advanced stage anaplastic large cell lymphoma (ALCL) is unknown. ANHL0131 examined whether a maintenance regimen including vinblastine compared to the standard APO (doxorubicin, prednisone, vincristine, methot... |