Sudebno-meditsinskaia ekspertiza 2012-01-01

[Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].

Ia I Korenman, V K Shormanov, N Ia Mokshina, O A Krivosheeva, D V Klimanov

Index: Sud. Med. Ekspert. 55(6) , 38-41, (2012)

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Abstract

The results of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions with organic solvents of different chemical nature and their mixtures are presented. Synergism between the distribution coefficients was demonstrated during the extraction of the above compounds with 1,4-dioxane and chloroform mixtures. The use of a chloroform--1,4-dioxane system in the molar ratio of 0.8:0.2 as a solvent resulted in the maximum values of distribution coefficients of 6-mercaptopurine and azathioprine.